|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternative_products
|
2 isoforms
|
|
gptkbp:associatedWith
|
gptkb:Diabetes_mellitus
gptkb:Hyperinsulinemia
|
|
gptkbp:chain
|
25-54 (B chain)
90-110 (A chain)
|
|
gptkbp:disulfideBond
|
A20-B19
A7-B7
A6-A11
|
|
gptkbp:EC_number
|
3.1.4.38
|
|
gptkbp:Entrez_Gene_ID
|
3630
ENSP00000250971
|
|
gptkbp:expressedIn
|
gptkb:Pancreatic_beta_cells
|
|
gptkbp:function
|
Regulation of glucose homeostasis
|
|
gptkbp:gene
|
gptkb:INS
|
|
gptkbp:HGNC_ID
|
HGNC:6081
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P21136
|
|
gptkbp:InterPro
|
gptkb:IPR022352
|
|
gptkbp:KEGGID
|
gptkb:hsa:3630
|
|
gptkbp:locatedOnChromosome
|
11
|
|
gptkbp:location
|
gptkb:11p15.5
|
|
gptkbp:molecularWeight
|
11793 Da
|
|
gptkbp:OMIM
|
176730
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:Insulin_signaling_pathway
Glucose metabolism
|
|
gptkbp:PDB
|
gptkb:1TRZ
gptkb:2HIU
gptkb:4EWW
3I3Z
|
|
gptkbp:postTranslationalModification
|
Disulfide bond
Cleavage on pair of basic residues
|
|
gptkbp:predecessor
|
gptkb:Proinsulin
|
|
gptkbp:protein_name
|
gptkb:Insulin
|
|
gptkbp:proteinFamily
|
gptkb:PF00049
|
|
gptkbp:Reactome
|
gptkb:R-HSA-264876
R-HSA-74713
R-HSA-74751
R-HSA-74752
R-HSA-74754
|
|
gptkbp:RefSeq
|
gptkb:NP_000198.1
|
|
gptkbp:sequence
|
110
|
|
gptkbp:signalPeptide
|
1-24
|
|
gptkbp:subcellularLocation
|
Secreted
|
|
gptkbp:tissue_specificity
|
Pancreas
|
|
gptkbp:UniGene
|
Hs.654653
|
|
gptkbp:UniProt_reviewed
|
Yes
|
|
gptkbp:UniProtID
|
gptkb:P21136
|
|
gptkbp:bfsParent
|
gptkb:LET-60_protein
|
|
gptkbp:bfsLayer
|
6
|