|
gptkbp:instanceOf
|
biological signaling pathway
|
|
gptkbp:alsoKnownAs
|
gptkb:Wnt_pathway
|
|
gptkbp:canonicalPathway
|
β-catenin dependent
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:bone
colorectal cancer
fibrosis
|
|
gptkbp:hasComponent
|
gptkb:Frizzled_receptor
gptkb:LRP5/6_co-receptor
gptkb:β-catenin
Wnt ligand
Destruction complex
TCF/LEF transcription factor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Wnt signaling
|
|
gptkbp:involves
|
gptkb:APC_protein
gptkb:Axin
gptkb:Dishevelled_proteins
gptkb:Frizzled_receptors
gptkb:GSK-3β
gptkb:TCF/LEF_transcription_factors
gptkb:Wnt_proteins
gptkb:β-catenin
|
|
gptkbp:modulatedBy
|
gptkb:R-spondin
gptkb:sFRP_proteins
gptkb:Tankyrase
gptkb:WIF-1
gptkb:DKK1
gptkb:Notum
Porcupine enzyme
|
|
gptkbp:namedAfter
|
gptkb:Int-1_(mouse_gene)
gptkb:Wingless_(Drosophila_gene)
|
|
gptkbp:nonCanonicalPathway
|
gptkb:Wnt/Ca2+_pathway
planar cell polarity pathway
|
|
gptkbp:pathway
|
canonical Wnt pathway
non-canonical Wnt pathway
|
|
gptkbp:regulates
|
cell proliferation
cell migration
cell fate determination
cell polarity
stem cell renewal
|
|
gptkbp:requires
|
embryonic development
organogenesis
tissue homeostasis
|
|
gptkbp:studiedIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Drosophila_melanogaster
|
|
gptkbp:target
|
monoclonal antibodies
small molecule inhibitors
therapeutic drugs
|
|
gptkbp:bfsParent
|
gptkb:Axin
gptkb:NANOG
gptkb:FOSL2
gptkb:SNAI1
|
|
gptkbp:bfsLayer
|
7
|