Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activity |
gptkb:hydrolase
|
| gptkbp:alternativeName |
PLA2
phosphatidylcholine 2-acylhydrolase |
| gptkbp:associatedWith |
signal transduction
allergic response host defense cell membrane remodeling lipid mediator production snakebite toxicity |
| gptkbp:catalyzes |
hydrolysis of the sn-2 acyl bond of phospholipids
|
| gptkbp:cofactor |
calcium (for some isoforms)
|
| gptkbp:discoveredBy |
early 20th century
|
| gptkbp:EC_number |
3.1.1.4
|
| gptkbp:family |
phospholipases
|
| gptkbp:foundIn |
gptkb:Bacteria
mammals pancreas snake venom inflammatory cells |
| gptkbp:gene |
PLA2G1B (for group IB)
PLA2G2A (for group IIA) PLA2G4A (for group IVA) |
| gptkbp:hasIsoform |
calcium-independent phospholipase A2 (iPLA2)
cytosolic phospholipase A2 (cPLA2) secretory phospholipase A2 (sPLA2) |
| https://www.w3.org/2000/01/rdf-schema#label |
Phospholipase A2
|
| gptkbp:inhibitedBy |
methyl arachidonyl fluorophosphonate
varespladib |
| gptkbp:involves |
inflammation
arachidonic acid release eicosanoid synthesis |
| gptkbp:molecularWeight |
13-18 kDa (for sPLA2)
|
| gptkbp:PDB |
1POC
|
| gptkbp:product |
lysophospholipid
free fatty acid |
| gptkbp:significance |
atherosclerosis
neurodegenerative diseases pancreatitis rheumatoid arthritis |
| gptkbp:structure |
alpha-helical
|
| gptkbp:substrate |
phosphatidylcholine
phosphatidylethanolamine phosphatidylserine |
| gptkbp:UniProtID |
P04054 (human group IB)
P14555 (human group IIA) P47712 (human group IVA) |
| gptkbp:bfsParent |
gptkb:Phospholipase
|
| gptkbp:bfsLayer |
7
|