|
gptkbp:instanceOf
|
gptkb:signaling_molecule
|
|
gptkbp:activatedBy
|
stress
cytokines
growth factors
UV radiation
osmotic shock
|
|
gptkbp:alsoKnownAs
|
gptkb:Mitogen-Activated_Protein_Kinase_pathway
|
|
gptkbp:component
|
gptkb:MAPK
gptkb:RAF
gptkb:JNK
gptkb:MKK
gptkb:ERK
gptkb:MEK
gptkb:MAP2K
gptkb:MAP3K
gptkb:MKKK
gptkb:p38
|
|
gptkbp:contains
|
gptkb:ERK_pathway
gptkb:JNK_pathway
gptkb:p38_MAPK_pathway
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:firstDescribed
|
1990s
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:inhibitedBy
|
gptkb:MEK_inhibitors
gptkb:RAF_inhibitors
ERK inhibitors
|
|
gptkbp:involves
|
gptkb:MAP_kinase
gptkb:MAP_kinase_kinase
gptkb:MAP_kinase_kinase_kinase
|
|
gptkbp:phosphorylates
|
transcription factors
cytoskeletal proteins
other kinases
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
cell survival
gene expression
|
|
gptkbp:requires
|
gptkb:immune_response
gptkb:cellular_stress_response
embryonic development
|
|
gptkbp:studiedIn
|
gptkb:yeast
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
mammals
|
|
gptkbp:target
|
therapeutic drugs
|
|
gptkbp:bfsParent
|
gptkb:Ras_GTPases
gptkb:NRAS_protein
gptkb:RalGDS_pathway
gptkb:Ras-Raf-MEK-ERK_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPK pathway
|