|
gptkbp:instanceOf
|
signaling molecule
|
|
gptkbp:activatedBy
|
gptkb:insulin
cytokines
growth factors
|
|
gptkbp:alsoKnownAs
|
gptkb:PI3K/AKT_pathway
|
|
gptkbp:component
|
gptkb:PI3K
gptkb:AKT
gptkb:PDK1
gptkb:PTEN
gptkb:mTOR
|
|
gptkbp:downstreamOf
|
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
|
|
gptkbp:firstDescribed
|
1990s
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PI3K-Akt pathway
|
|
gptkbp:inhibitedBy
|
gptkb:PTEN
|
|
gptkbp:involves
|
gptkb:AKT_(protein_kinase_B)
gptkb:protein
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:mutationAssociatedWith
|
gptkb:PTEN_gene
gptkb:AKT1_gene
gptkb:PIK3CA_gene
|
|
gptkbp:phosphorylates
|
gptkb:AKT
gptkb:FOXO_transcription_factors
gptkb:GSK3
gptkb:mTOR
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
cell survival
metabolism
angiogenesis
cell cycle progression
cell growth
cell migration
glucose uptake
protein synthesis
autophagy
|
|
gptkbp:studiedIn
|
neuroscience
oncology
metabolic diseases
|
|
gptkbp:target
|
AKT inhibitors
PI3K inhibitors
anticancer drugs
mTOR inhibitors
|
|
gptkbp:bfsParent
|
gptkb:c-Met
gptkb:Ras-Raf-MEK-ERK_pathway
gptkb:Ras_signaling_pathway
gptkb:Platelet-derived_growth_factor
gptkb:human_interleukin-6
|
|
gptkbp:bfsLayer
|
6
|