Insulin-like growth factor 1

URI: https://gptkb.org/entity/Insulin-like_growth_factor_1
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
hormone
gptkbp:abbreviation gptkb:IGF-1
gptkbp:alternativeName somatomedin C
gptkbp:associatedWith gptkb:cancer
gptkb:Laron_syndrome
acromegaly
gptkbp:binds gptkb:IGF-binding_proteins
gptkbp:category endocrinology
growth factors
human proteins
peptide hormones
gptkbp:discoveredBy 1957
gptkbp:encodedBy gptkb:IGF1_gene
gptkbp:Entrez_Gene_ID 3479
gptkbp:foundIn humans
other mammals
gptkbp:function mediates effects of growth hormone
regulates cell growth and development
stimulates systemic body growth
gptkbp:halfLife 12-15 hours
gptkbp:HGNC_ID 5464
https://www.w3.org/2000/01/rdf-schema#label Insulin-like growth factor 1
gptkbp:locatedOnChromosome chromosome 12q23.2
gptkbp:medicalUse diagnosis of growth disorders
monitoring acromegaly
monitoring gigantism
gptkbp:MeSH_ID D007333
gptkbp:OMIM 147440
gptkbp:PDB 1IMX
gptkbp:producedBy liver
other tissues
gptkbp:recipient gptkb:IGF-1_receptor
gptkbp:RefSeq NM_000618
gptkbp:regulates inhibited by chronic disease
inhibited by malnutrition
stimulated by growth hormone
gptkbp:relatedTo gptkb:insulin
recombinant human growth hormone
gptkbp:sequence 70 amino acids
gptkbp:structure single-chain polypeptide
gptkbp:UniProtID P05019
gptkbp:bfsParent gptkb:IGF1
gptkb:IGF-I
gptkb:Pancreatic_beta_cells
gptkb:Somatomedin-A
gptkb:IGF-1
gptkbp:bfsLayer 8