Statements (74)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
glucose metabolism
metabolic syndrome obesity chronic kidney disease insulin resistance type 1 diabetes |
| gptkbp:belongs_to |
class BG protein-coupled receptors
|
| gptkbp:community |
lipid metabolism
appetite inflammatory responses insulin signaling glucose levels hormonal responses hormonal secretion neurotransmitter activity sympathetic nervous system activity glucose-dependent insulin secretion |
| gptkbp:discovered_by |
1990s
|
| gptkbp:enhances |
beta cell proliferation
|
| gptkbp:established |
appetite
intracellular signaling pathways exendin-4 glucagon release |
| gptkbp:function |
binds to GLP-1
|
| https://www.w3.org/2000/01/rdf-schema#label |
GLP-1 receptor
|
| gptkbp:influences |
energy homeostasis
metabolic rate insulin sensitivity energy expenditure cholesterol levels lipid profiles glucose homeostasis vascular health gastric emptying glucose uptake muscle metabolism metabolic flexibility beta cell function satiety signals |
| gptkbp:interacts_with |
G proteins
GLP-1 receptor antagonists beta-arrestins other GPC Rs |
| gptkbp:is_aimed_at |
gptkb:liraglutide
gptkb:semaglutide gptkb:dulaglutide GLP-1 receptor agonists |
| gptkbp:is_involved_in |
cell differentiation
cell growth cell signaling neurotransmitter release weight loss cognitive function cardiovascular health cell survival neuroprotection cellular signaling pathways neuroendocrine signaling cellular communication hormonal balance insulin secretion cellular repair mechanisms diabetes complications cell apoptosis inflammation regulation |
| gptkbp:is_represented_in |
pancreatic beta cells
intestinal L cells |
| gptkbp:location |
cell membrane
|
| gptkbp:products |
GLP-1 peptide
|
| gptkbp:promoter |
GL P1 R
|
| gptkbp:research_areas |
type 2 diabetes treatment
|
| gptkbp:bfsParent |
gptkb:Tirzepatide
|
| gptkbp:bfsLayer |
4
|