|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:binds
|
gptkb:glucagon-like_peptide-1
|
|
gptkbp:discoveredBy
|
1992
|
|
gptkbp:encodedBy
|
gptkb:GLP1R_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:GLP1R
|
|
gptkbp:expressedIn
|
gptkb:islets_of_Langerhans
central nervous system
peripheral tissues
|
|
gptkbp:foundIn
|
gptkb:cancer
gptkb:human
gptkb:kidney
brain
heart
gastrointestinal tract
pancreatic beta cells
|
|
gptkbp:function
|
cardioprotection
appetite suppression
regulation of insulin secretion
regulation of glucagon secretion
slowing gastric emptying
|
|
gptkbp:HGNC_ID
|
4317
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GLP-1 receptor
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21
|
|
gptkbp:modulatedBy
|
antagonists
agonists
|
|
gptkbp:OMIM
|
138032
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:relatedTo
|
gptkb:cardiovascular_disease
gptkb:type_2_diabetes
obesity
weight loss
|
|
gptkbp:structure
|
7 transmembrane domains
|
|
gptkbp:target
|
gptkb:albiglutide
gptkb:exenatide
gptkb:liraglutide
gptkb:lixisenatide
gptkb:semaglutide
gptkb:dulaglutide
gptkb:GLP-1_receptor_agonists
|
|
gptkbp:targetOfDrug
|
anti-obesity drugs
antidiabetic drugs
|
|
gptkbp:type
|
gptkb:cAMP_pathway
gptkb:Gs_protein
|
|
gptkbp:UniProtID
|
P43220
|
|
gptkbp:bfsParent
|
gptkb:GLP-1_(Glucagon-like_peptide-1)
gptkb:GLP-1
|
|
gptkbp:bfsLayer
|
7
|