|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
IPF1
IDX-1
IUF1
STF-1
|
|
gptkbp:discoveredBy
|
gptkb:Christopher_Wright
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:domain
|
homeodomain
|
|
gptkbp:encodes
|
PDX1 protein
|
|
gptkbp:Entrez_Gene_ID
|
3651
ENSG00000139515
|
|
gptkbp:expressedIn
|
gptkb:duodenum
pancreas
|
|
gptkbp:fullName
|
Pancreatic and duodenal homeobox 1
|
|
gptkbp:function
|
transcription factor
regulates insulin gene expression
regulates pancreatic development
|
|
gptkbp:HGNC_ID
|
HGNC:3750
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDX1
|
|
gptkbp:length
|
283
|
|
gptkbp:locatedOnChromosome
|
13q12.2
|
|
gptkbp:molecularWeight
|
31 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:diabetes_mellitus
pancreatic agenesis
MODY4
|
|
gptkbp:OMIM
|
600733
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Pdx1
|
|
gptkbp:RefSeq
|
NM_000209
|
|
gptkbp:regulates
|
gptkb:INS
gptkb:IAPP
gptkb:GLUT2
gptkb:GCK
SST
homeobox
|
|
gptkbp:regulatesAlphaCellFunction
|
true
|
|
gptkbp:regulatesBetaCellFunction
|
true
|
|
gptkbp:regulatesDeltaCellFunction
|
true
|
|
gptkbp:regulatesDuodenalDevelopment
|
true
|
|
gptkbp:regulatesEndocrinePancreasDevelopment
|
true
|
|
gptkbp:regulatesExocrinePancreasDevelopment
|
true
|
|
gptkbp:regulatesPancreaticDevelopment
|
true
|
|
gptkbp:significance
|
pancreatic agenesis
monogenic diabetes
type 2 diabetes susceptibility
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
P52945
|
|
gptkbp:bfsParent
|
gptkb:16p13.13
|
|
gptkbp:bfsLayer
|
7
|