|
gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:activatedBy
|
gptkb:metformin
gptkb:AMP
gptkb:ADP
exercise
caloric restriction
|
|
gptkbp:alsoKnownAs
|
gptkb:AMP-activated_protein_kinase_pathway
|
|
gptkbp:component
|
gptkb:FOXO3
gptkb:GSK3β
gptkb:PRKAA1
gptkb:PRKAA2
gptkb:PRKAB1
gptkb:PRKAB2
gptkb:PRKAG1
gptkb:PRKAG2
gptkb:PRKAG3
gptkb:S6K
gptkb:TSC1
gptkb:TSC2
gptkb:ULK1
gptkb:CREB
gptkb:GLUT4
gptkb:SIRT1
gptkb:HMGCR
gptkb:bird
gptkb:Rheb
gptkb:mTORC1
gptkb:MFF
gptkb:p53
gptkb:HSL
gptkb:MCD
gptkb:IRS1
gptkb:eNOS
gptkb:p70S6K
gptkb:SREBP-1c
gptkb:ACC_(acetyl-CoA_carboxylase)
gptkb:ATGL
gptkb:AXIN
gptkb:CRTC2
gptkb:ChREBP
gptkb:Nrf2
gptkb:PGC-1α
gptkb:TBC1D1
gptkb:TORC2
LKB1 (liver kinase B1)
CaMKKβ (calcium/calmodulin-dependent protein kinase kinase beta)
|
|
gptkbp:discoveredBy
|
gptkb:D._Grahame_Hardie
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:foundIn
|
eukaryotic cells
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AMPK pathway
|
|
gptkbp:inhibitedBy
|
gptkb:ATP
|
|
gptkbp:involvedIn
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:type_2_diabetes
obesity
|
|
gptkbp:involvesProtein
|
gptkb:AMPK_(AMP-activated_protein_kinase)
|
|
gptkbp:regulates
|
gptkb:mTOR_pathway
apoptosis
cell proliferation
lipid metabolism
cell growth
glucose uptake
protein synthesis
inflammation
muscle contraction
autophagy
oxidative stress response
fatty acid oxidation
fatty acid synthesis
insulin sensitivity
mitochondrial biogenesis
mitophagy
circadian rhythm
gluconeogenesis
cholesterol synthesis
glycogen synthesis
adipose tissue metabolism
cardiac metabolism
cellular energy homeostasis
hypothalamic appetite regulation
liver metabolism
skeletal muscle metabolism
vascular function
|
|
gptkbp:target
|
gptkb:AICAR
gptkb:thiazolidinediones
gptkb:leptin
gptkb:rosiglitazone
gptkb:adiponectin
gptkb:phenformin
berberine
polyphenols
omega-3 fatty acids
resveratrol
salicylate
ghrelin
|
|
gptkbp:bfsParent
|
gptkb:mTOR_pathway
|
|
gptkbp:bfsLayer
|
5
|