|
gptkbp:instanceOf
|
gptkb:biological_pathway
|
|
gptkbp:activatedBy
|
gptkb:insulin
growth factors
amino acids
|
|
gptkbp:alsoKnownAs
|
gptkb:mechanistic_target_of_rapamycin_pathway
|
|
gptkbp:component
|
gptkb:mTORC1
gptkb:mTORC2
|
|
gptkbp:discoveredBy
|
gptkb:David_Sabatini
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:downstreamOf
|
gptkb:4EBP1
gptkb:S6K1
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
gptkb:diabetes
obesity
neurodegenerative diseases
|
|
gptkbp:inhibitedBy
|
gptkb:rapamycin
energy stress
nutrient deprivation
|
|
gptkbp:involvesProtein
|
gptkb:4EBP1
gptkb:Deptor
gptkb:PRAS40
gptkb:S6K
gptkb:TSC1
gptkb:TSC2
gptkb:mLST8
gptkb:bird
gptkb:AKT
gptkb:AMPK
gptkb:mTOR
gptkb:Rictor
|
|
gptkbp:location
|
gptkb:lysosome
gptkb:cytoplasm
|
|
gptkbp:regulates
|
cell proliferation
cell survival
cell growth
protein synthesis
autophagy
cell motility
|
|
gptkbp:relatedTo
|
gptkb:PI3K/AKT_pathway
gptkb:AMPK_pathway
insulin signaling pathway
|
|
gptkbp:target
|
gptkb:everolimus
gptkb:rapalogs
gptkb:sirolimus
gptkb:temsirolimus
|
|
gptkbp:upregulatedBy
|
gptkb:PI3K
gptkb:PTEN
|
|
gptkbp:bfsParent
|
gptkb:PI3K
|
|
gptkbp:bfsLayer
|
5
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mTOR pathway
|