|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:abbreviation
|
gptkb:PKC
|
|
gptkbp:activatedBy
|
phospholipids
calcium ions
diacylglycerol
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
bipolar disorder
|
|
gptkbp:cofactor
|
gptkb:ATP
Mg2+
|
|
gptkbp:discoveredBy
|
gptkb:Yasutomi_Nishizuka
|
|
gptkbp:discoveredIn
|
1977
|
|
gptkbp:enzymeClassification
|
EC 2.7.11.13
|
|
gptkbp:family
|
protein kinases
|
|
gptkbp:function
|
phosphorylation of serine and threonine residues
|
|
gptkbp:GO_term
|
gptkb:GO:0004697
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Protein kinase C
|
|
gptkbp:inhibitedBy
|
gptkb:Gö_6983
gptkb:chelerythrine
gptkb:staurosporine
bisindolylmaleimide I
calphostin C
|
|
gptkbp:location
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gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
70-90 kDa
|
|
gptkbp:orthologInMouse
|
Prkca
|
|
gptkbp:orthologInYeast
|
PKC1
|
|
gptkbp:PDB
|
2I0E
|
|
gptkbp:phosphorylates
|
gptkb:histone_H1
gptkb:GAP-43
gptkb:myristoylated_alanine-rich_C-kinase_substrate
MARCKS protein
|
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gptkbp:proteinFamily
|
gptkb:PRKCA
gptkb:PRKCB
gptkb:PRKCD
gptkb:PRKCE
gptkb:PRKCG
gptkb:PRKCH
gptkb:PRKCI
gptkb:PRKCZ
PRKCN
|
|
gptkbp:reviewedBy
|
gptkb:Annual_Review_of_Biochemistry
gptkb:Nature_Reviews_Molecular_Cell_Biology
|
|
gptkbp:role
|
apoptosis
cell proliferation
differentiation
signal transduction
tumor promotion
|
|
gptkbp:structure
|
regulatory domain
catalytic domain
|
|
gptkbp:subspecies
|
atypical PKC
conventional PKC
novel PKC
|
|
gptkbp:substrate
|
proteins with serine/threonine residues
|
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gptkbp:UniProtID
|
gptkb:P17252_(PKC_alpha)
|
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gptkbp:bfsParent
|
gptkb:PKC
|
|
gptkbp:bfsLayer
|
6
|