Platelet-derived growth factor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:PDGF
gptkbp:category	growth factor cytokine
gptkbp:discoveredBy	gptkb:Russell_Ross gptkb:Ulla_Westermark
gptkbp:discoveredIn	1974
gptkbp:foundIn	gptkb:human gptkb:mouse right
gptkbp:function	cell proliferation wound healing angiogenesis cell growth
gptkbp:gene	gptkb:PDGFC gptkb:PDGFD gptkb:PDGFA gptkb:PDGFB
gptkbp:GO_term	GO:0008083
https://www.w3.org/2000/01/rdf-schema#label	Platelet-derived growth factor
gptkbp:inhibitedBy	gptkb:sorafenib gptkb:imatinib gptkb:pazopanib gptkb:sunitinib
gptkbp:pathway	gptkb:MAPK_pathway gptkb:PI3K-Akt_pathway gptkb:JAK-STAT_pathway
gptkbp:producedBy	macrophages platelets endothelial cells smooth muscle cells
gptkbp:recipient	gptkb:PDGF_receptor_alpha gptkb:PDGF_receptor_beta
gptkbp:regulates	cell differentiation chemotaxis extracellular matrix production mesenchymal cell proliferation
gptkbp:relatedTo	gptkb:vascular_endothelial_growth_factor fibroblast growth factor
gptkbp:role	gptkb:cancer gptkb:glioblastoma atherosclerosis fibrosis pulmonary arterial hypertension
gptkbp:structure	dimer
gptkbp:subunit	A chain B chain C chain D chain
gptkbp:UniProtID	P04085
gptkbp:bfsParent	gptkb:Platelet
gptkbp:bfsLayer	5