Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:signaling_molecule
|
| gptkbp:activatedBy |
gptkb:receptor_tyrosine_kinases
growth factors |
| gptkbp:alsoKnownAs |
gptkb:MAPK/ERK_pathway
|
| gptkbp:component |
gptkb:Raf
gptkb:Ras |
| gptkbp:downstreamOf |
gptkb:EGFR
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
developmental disorders |
| gptkbp:fourthComponent |
gptkb:ERK
|
| gptkbp:inhibitedBy |
gptkb:MEK_inhibitors
ERK inhibitors Raf inhibitors |
| gptkbp:involvesProtein |
gptkb:ERK
gptkb:MEK gptkb:Raf gptkb:Ras |
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:phosphorylates |
transcription factors
|
| gptkbp:regulates |
cell differentiation
cell proliferation cell survival |
| gptkbp:relatedTo |
gptkb:MAPK_pathway
gptkb:PI3K-Akt_pathway |
| gptkbp:studiedIn |
cell biology
oncology |
| gptkbp:thirdComponent |
gptkb:MEK
|
| gptkbp:type |
kinase cascade
|
| gptkbp:bfsParent |
gptkb:MAPK/ERK_pathway
|
| gptkbp:bfsLayer |
5
|
| https://www.w3.org/2000/01/rdf-schema#label |
Ras-Raf-MEK-ERK pathway
|