Statements (32)
Predicate | Object |
---|---|
gptkbp:instanceOf |
signaling molecule
|
gptkbp:activatedBy |
gptkb:receptor_tyrosine_kinases
growth factors |
gptkbp:alsoKnownAs |
gptkb:MAPK/ERK_pathway
|
gptkbp:component |
gptkb:Raf
gptkb:Ras |
gptkbp:downstreamOf |
gptkb:EGFR
|
gptkbp:dysregulationAssociatedWith |
gptkb:cancer
developmental disorders |
gptkbp:fourthComponent |
gptkb:ERK
|
https://www.w3.org/2000/01/rdf-schema#label |
Ras-Raf-MEK-ERK pathway
|
gptkbp:inhibitedBy |
gptkb:MEK_inhibitors
ERK inhibitors Raf inhibitors |
gptkbp:involvesProtein |
gptkb:ERK
gptkb:MEK gptkb:Raf gptkb:Ras |
gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
gptkbp:phosphorylates |
transcription factors
|
gptkbp:regulates |
cell differentiation
cell proliferation cell survival |
gptkbp:relatedTo |
gptkb:MAPK_pathway
gptkb:PI3K-Akt_pathway |
gptkbp:studiedIn |
cell biology
oncology |
gptkbp:thirdComponent |
gptkb:MEK
|
gptkbp:type |
kinase cascade
|
gptkbp:bfsParent |
gptkb:MAPK/ERK_pathway
|
gptkbp:bfsLayer |
5
|