transforming growth factor alpha

URI: https://gptkb.org/entity/transforming_growth_factor_alpha
GPTKB entity
Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation TGF-α
gptkbp:associatedWith gptkb:cancer
neoplasia
gptkbp:category growth factor
cytokine
gptkbp:cleavage gptkb:ADAM17
gptkbp:discoveredBy gptkb:Mariano_Barbacid
gptkbp:discoveredIn 1980s
gptkbp:encodedBy gptkb:TGFA_gene
gptkbp:expressedIn gptkb:cancer
gptkb:kidney
gptkb:placenta
mammary gland
epithelial tissues
developing brain
gptkbp:foundIn humans
mice
rats
gptkbp:function cell proliferation
wound healing
growth factor activity
epithelial development
gptkbp:gene gptkb:TGFA
gptkbp:GOProcess cellular response to growth factor stimulus
gptkbp:HGNC_ID 11766
https://www.w3.org/2000/01/rdf-schema#label transforming growth factor alpha
gptkbp:inhibitedBy apoptosis
gptkbp:length 160 amino acids (precursor)
gptkbp:locatedOnChromosome chromosome 2p13
gptkbp:OMIM 190170
gptkbp:orthologIn gptkb:epidermal_growth_factor
gptkbp:PDB 1TGF
gptkbp:postTranslationalModification glycosylation
proteolytic cleavage
gptkbp:processedForm 50 amino acids (mature)
gptkbp:promotion angiogenesis
cell migration
DNA synthesis
gptkbp:recipient gptkb:epidermal_growth_factor_receptor
gptkbp:RefSeq NP_003227.1
gptkbp:relatedTo gptkb:epidermal_growth_factor
gptkbp:role tissue regeneration
embryogenesis
tumorigenesis
gptkbp:secretes gptkb:keratinocytes
macrophages
astrocytes
gptkbp:structure contains EGF-like domain
gptkbp:UniProtID gptkb:P01135
gptkbp:bfsParent gptkb:EGFR
gptkb:P42338
gptkbp:bfsLayer 6