epidermal growth factor receptor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:receptor_tyrosine_kinase gptkb:protein
gptkbp:abbreviation	gptkb:EGFR
gptkbp:alternativeName	gptkb:HER1 ErbB-1
gptkbp:associatedWith	gptkb:non-small_cell_lung_cancer gptkb:glioblastoma colorectal cancer
gptkbp:biologicalProcess	receptor tyrosine kinase activity
gptkbp:dimerization	homodimer heterodimer with ErbB2
gptkbp:discoveredBy	gptkb:Stanley_Cohen
gptkbp:discoveredIn	1978
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000146648
gptkbp:expressedIn	epithelial tissues
gptkbp:function	cell signaling regulation of cell proliferation regulation of cell growth
gptkbp:gene	gptkb:EGFR gptkb:EGFR_gene
gptkbp:HGNC_ID	3236
https://www.w3.org/2000/01/rdf-schema#label	epidermal growth factor receptor
gptkbp:ligand	gptkb:epidermal_growth_factor gptkb:transforming_growth_factor_alpha
gptkbp:locatedOnChromosome	gptkb:chromosome_7
gptkbp:location	gptkb:cell_membrane
gptkbp:member	gptkb:ErbB_family
gptkbp:molecularWeight	170 kDa
gptkbp:mutationAssociatedWith	gptkb:L858R gptkb:T790M exon 19 deletion
gptkbp:number_of_amino_acids	1210
gptkbp:OMIM	131550
gptkbp:orthologInMouse	Egfr
gptkbp:pathway	gptkb:MAPK/ERK_pathway gptkb:PI3K/AKT_pathway gptkb:JAK/STAT_pathway
gptkbp:PDB	1M17
gptkbp:phosphorylates	tyrosine residues
gptkbp:postTranslationalModification	phosphorylation glycosylation ubiquitination
gptkbp:targetOfDrug	gptkb:afatinib gptkb:cetuximab gptkb:erlotinib gptkb:gefitinib gptkb:osimertinib
gptkbp:UniProtID	gptkb:P00533
gptkbp:bfsParent	gptkb:EGFR gptkb:EGFR_gene gptkb:Erbitux
gptkbp:bfsLayer	6