|
gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:activatedBy
|
gptkb:epidermal_growth_factor_(EGF)
heregulin
|
|
gptkbp:cause
|
cell differentiation
cell proliferation
cell survival
cell migration
|
|
gptkbp:downstreamEffectors
|
gptkb:PLCĪ³_pathway
gptkb:STAT_pathway
gptkb:PI3K/AKT_pathway
gptkb:RAS/MAPK_pathway
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:GO_term
|
GO:0038127
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ErbB signaling pathway
|
|
gptkbp:includes
|
EGFR (ErbB1)
ErbB2 (HER2/neu)
ErbB3
ErbB4
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:glioblastoma
colorectal cancer
signal transduction
head and neck cancer
gastric cancer
autophosphorylation
ErbB family of receptor tyrosine kinases
ligand-induced dimerization
|
|
gptkbp:KEGGID
|
hsa04012
|
|
gptkbp:modulatedBy
|
gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
gptkb:pertuzumab
gptkb:trastuzumab
gptkb:tucatinib
gptkb:dacomitinib
gptkb:lapatinib
gptkb:neratinib
gptkb:panitumumab
canertinib
poziotinib
sapitinib
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:target
|
monoclonal antibodies
tyrosine kinase inhibitors
|
|
gptkbp:WikiPathways_ID
|
WP673
|
|
gptkbp:bfsParent
|
gptkb:EGFR
gptkb:P42336
|
|
gptkbp:bfsLayer
|
6
|