|
gptkbp:instanceOf
|
gptkb:cancer
brain tumor
glioma
|
|
gptkbp:abbreviation
|
GBM
|
|
gptkbp:affectsOrgan
|
brain
|
|
gptkbp:clinicalTrialPhase
|
gptkb:NCT02667587
gptkb:NCT03400917
|
|
gptkbp:firstDescribed
|
gptkb:Harvey_Cushing
gptkb:Percival_Bailey
1926
|
|
gptkbp:frequency
|
rare
|
|
gptkbp:grades
|
gptkb:WHO_grade_IV
|
|
gptkbp:hasCommonTreatment
|
surgery
radiation therapy
chemotherapy
|
|
gptkbp:hasEpidemiology
|
most common primary malignant brain tumor in adults
|
|
gptkbp:hasGeneticAlteration
|
gptkb:TP53_mutation
EGFR amplification
IDH1 mutation
PTEN mutation
|
|
gptkbp:hasHistopathology
|
microvascular proliferation
necrosis
|
|
gptkbp:hasICD9Code
|
191.0
|
|
gptkbp:hasImagingFinding
|
ring-enhancing lesion on MRI
|
|
gptkbp:hasMedianSurvival
|
12-15 months
|
|
gptkbp:hasOrphanetID
|
gptkb:ORPHA:447
|
|
gptkbp:hasPeakIncidenceAge
|
45-70 years
|
|
gptkbp:hasStandardOfCare
|
gptkb:Stupp_protocol
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
glioblastoma
|
|
gptkbp:ICD-10_code
|
C71
|
|
gptkbp:location
|
frontal lobe
temporal lobe
cerebral hemispheres
|
|
gptkbp:MeSH_ID
|
gptkb:D005909
|
|
gptkbp:mortalityRate
|
high
|
|
gptkbp:OMIM
|
137800
|
|
gptkbp:originatedIn
|
astrocyte
|
|
gptkbp:prevalence
|
3.2 per 100,000 people per year
|
|
gptkbp:prognosis
|
poor
|
|
gptkbp:recurrence
|
high
|
|
gptkbp:riskFactor
|
age
radiation therapy
male sex
|
|
gptkbp:stageName
|
gptkb:WHO_classification
|
|
gptkbp:symptom
|
nausea
vomiting
headache
cognitive impairment
seizures
personality change
|
|
gptkbp:synonym
|
gptkb:glioblastoma_multiforme
|
|
gptkbp:bfsParent
|
gptkb:John_McCain
gptkb:The_Cancer_Genome_Atlas
gptkb:protein
|
|
gptkbp:bfsLayer
|
4
|