|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:EGFR
|
|
gptkbp:associatedWith
|
gptkb:non-small_cell_lung_cancer
gptkb:glioblastoma
colorectal cancer
head and neck cancer
|
|
gptkbp:clinicalTrialPhase
|
EGFR mutation analysis
|
|
gptkbp:discoveredBy
|
gptkb:Axel_Ullrich
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:encodes
|
gptkb:epidermal_growth_factor_receptor
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000146648
1956
|
|
gptkbp:expressedIn
|
epithelial tissues
|
|
gptkbp:function
|
cell differentiation regulation
cell proliferation regulation
receptor tyrosine kinase activity
|
|
gptkbp:HGNC_ID
|
3236
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ERBB1
|
|
gptkbp:interactsWith
|
gptkb:PIK3R1
gptkb:SHC1
gptkb:SRC
gptkb:GRB2
gptkb:STAT3
|
|
gptkbp:locatedOnChromosome
|
gptkb:7p11.2
|
|
gptkbp:memberOf
|
ERBB family
|
|
gptkbp:mutationAssociatedWith
|
deletion
point mutation
amplification
oncogenic activation
|
|
gptkbp:OMIM
|
131550
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Egfr
|
|
gptkbp:orthologInZebrafish
|
egfra
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:ErbB_signaling_pathway
|
|
gptkbp:phosphorylates
|
Y1068
Y1148
Y1173
Y992
|
|
gptkbp:product
|
gptkb:EGFR_protein
|
|
gptkbp:target
|
gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
|
|
gptkbp:targetOfDrug
|
gptkb:cancer
colorectal cancer
head and neck cancer
|
|
gptkbp:UniProtID
|
gptkb:P00533
|
|
gptkbp:bfsParent
|
gptkb:EGFR
gptkb:EGFR_gene
gptkb:P15056
gptkb:P42336
gptkb:P42338
|
|
gptkbp:bfsLayer
|
6
|