epidermal growth factor receptor protein

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:receptor_tyrosine_kinase gptkb:protein
gptkbp:alternativeName	gptkb:EGFR gptkb:HER1 ErbB-1
gptkbp:binds	gptkb:epidermal_growth_factor gptkb:transforming_growth_factor_alpha
gptkbp:domain	transmembrane domain extracellular ligand-binding domain intracellular tyrosine kinase domain
gptkbp:encodedBy	gptkb:EGFR_gene
gptkbp:form	homodimer heterodimer with ErbB2
gptkbp:foundIn	gptkb:human gptkb:mouse other mammals
gptkbp:function	cell signaling regulation of cell differentiation regulation of cell proliferation regulation of cell growth
gptkbp:hasBiologicalActivity	gptkb:receptor_tyrosine_kinase
gptkbp:involvedIn	gptkb:cancer gptkb:glioblastoma colorectal cancer
gptkbp:locatedIn	gptkb:cell_membrane
gptkbp:locatedOnChromosome	gptkb:7p11.2
gptkbp:memberOf	gptkb:ErbB_family
gptkbp:mutationAssociatedWith	gptkb:non-small_cell_lung_cancer gptkb:glioblastoma_multiforme head and neck cancer
gptkbp:OMIM	131550
gptkbp:PDB	1M17 2GS6 2ITX 3POZ
gptkbp:phosphorylates	tyrosine residues
gptkbp:regulates	gptkb:MAPK_pathway gptkb:PLCγ_pathway gptkb:PI3K/AKT_pathway gptkb:JAK/STAT_pathway
gptkbp:target	gptkb:afatinib gptkb:cetuximab gptkb:erlotinib gptkb:gefitinib gptkb:osimertinib
gptkbp:UniProtID	gptkb:P00533
gptkbp:bfsParent	gptkb:EGFR gptkb:EGFR_gene
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	epidermal growth factor receptor protein