epidermal growth factor receptor protein

URI: https://gptkb.org/entity/epidermal_growth_factor_receptor_protein
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:alternativeName gptkb:EGFR
gptkb:HER1
ErbB-1
gptkbp:binds gptkb:epidermal_growth_factor
gptkb:transforming_growth_factor_alpha
gptkbp:domain transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
gptkbp:encodedBy gptkb:EGFR_gene
gptkbp:form homodimer
heterodimer with ErbB2
gptkbp:foundIn gptkb:human
gptkb:mouse
other mammals
gptkbp:function cell signaling
regulation of cell differentiation
regulation of cell proliferation
regulation of cell growth
gptkbp:hasBiologicalActivity gptkb:receptor_tyrosine_kinase
https://www.w3.org/2000/01/rdf-schema#label epidermal growth factor receptor protein
gptkbp:involvedIn gptkb:cancer
gptkb:glioblastoma
colorectal cancer
gptkbp:locatedIn gptkb:cell_membrane
gptkbp:locatedOnChromosome gptkb:7p11.2
gptkbp:memberOf gptkb:ErbB_family
gptkbp:mutationAssociatedWith gptkb:non-small_cell_lung_cancer
gptkb:glioblastoma_multiforme
head and neck cancer
gptkbp:OMIM 131550
gptkbp:PDB 1M17
2GS6
2ITX
3POZ
gptkbp:phosphorylates tyrosine residues
gptkbp:regulates gptkb:MAPK_pathway
gptkb:PLCĪ³_pathway
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
gptkbp:target gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
gptkbp:UniProtID gptkb:P00533
gptkbp:bfsParent gptkb:EGFR
gptkb:EGFR_gene
gptkbp:bfsLayer 6