|
gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:activatedBy
|
gptkb:PI3K-AKT_pathway
gptkb:PLCγ_pathway
gptkb:RAS-RAF-MEK-ERK_pathway
gptkb:STAT_pathway
|
|
gptkbp:alsoKnownAs
|
gptkb:Epidermal_Growth_Factor_Receptor_signaling_pathway
|
|
gptkbp:component
|
gptkb:EGF
gptkb:HB-EGF
gptkb:PLCγ
gptkb:STATs
gptkb:TGF-alpha
gptkb:amphiregulin
gptkb:betacellulin
gptkb:epiregulin
gptkb:PI3K
gptkb:RAS
gptkb:RAF
gptkb:SOS
gptkb:AKT
gptkb:ERK
gptkb:GRB2
gptkb:MEK
neuregulins
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:non-small_cell_lung_cancer
gptkb:cancer
gptkb:glioblastoma
colorectal cancer
|
|
gptkbp:encodedBy
|
gptkb:EGFR_gene
|
|
gptkbp:foundIn
|
humans
mammals
vertebrates
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EGFR signaling pathway
|
|
gptkbp:involves
|
gptkb:EGFR
autophosphorylation
ligand binding
receptor dimerization
|
|
gptkbp:launched
|
EGF binding to EGFR
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:recipient
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
cell migration
cell adhesion
|
|
gptkbp:target
|
gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
|
|
gptkbp:bfsParent
|
gptkb:KRAS
|
|
gptkbp:bfsLayer
|
5
|