Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:activatedBy |
ligand binding
|
| gptkbp:alternativeName |
gptkb:RTKs
|
| gptkbp:contains |
transmembrane domain
extracellular ligand-binding domain intracellular tyrosine kinase domain |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:diabetes developmental disorders |
| gptkbp:example |
gptkb:EGFR
gptkb:FGFR gptkb:Insulin_receptor gptkb:PDGFR gptkb:VEGFR gptkb:c-Met |
| gptkbp:foundIn |
animals
humans |
| gptkbp:function |
signal transduction
phosphorylation of tyrosine residues |
| gptkbp:gene |
RTK genes
|
| https://www.w3.org/2000/01/rdf-schema#label |
receptor tyrosine kinases
|
| gptkbp:inhibitedBy |
tyrosine kinase inhibitors
|
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:mechanismOfAction |
autophosphorylation
|
| gptkbp:numberOfFamilies |
20
|
| gptkbp:role |
cell differentiation
cell survival cell growth cell migration |
| gptkbp:bfsParent |
gptkb:protein
|
| gptkbp:bfsLayer |
4
|