|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
cell surface receptor
|
|
gptkbp:activatedBy
|
ligand binding
|
|
gptkbp:alternativeName
|
gptkb:RTK
protein-tyrosine kinase receptor
receptor
serotonin_receptor
tyrosine_kinase
tyrosine_kinase_inhibitor
|
|
gptkbp:binds
|
serotonin
|
|
gptkbp:catalyzes
|
phosphorylation of tyrosine residues
|
|
gptkbp:compatibleWith
|
prokaryotes
|
|
gptkbp:contains
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:discoveredBy
|
gptkb:Rita_Levi-Montalcini
gptkb:Stanley_Cohen
|
|
gptkbp:discoveredIn
|
20th century
|
|
gptkbp:encodedBy
|
various genes
|
|
gptkbp:example
|
gptkb:EGFR
gptkb:FGFR
gptkb:PDGFR
gptkb:VEGFR
gptkb:insulin_receptor
|
|
gptkbp:excludes
|
5-HT3 receptor is ligand-gated ion channel
|
|
gptkbp:expressedIn
|
gastrointestinal tract
neurons
platelets
smooth muscle cells
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:foundIn
|
animals
humans
plants
central nervous system
peripheral nervous system
|
|
gptkbp:function
|
signal transduction
modulates neurotransmission
regulates appetite
regulates learning
regulates memory
regulates mood
regulates sleep
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
receptor tyrosine kinase
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:diabetes
cell differentiation
cell survival
angiogenesis
cell growth
cell metabolism
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:mechanismOfAction
|
autophosphorylation
dimerization upon ligand binding
|
|
gptkbp:mutation_can_cause
|
developmental disorders
oncogenesis
|
|
gptkbp:number_of_subfamilies
|
20
|
|
gptkbp:proteinFamily
|
RTK family
|
|
gptkbp:structure
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:subspecies
|
gptkb:5-HT1_receptor
gptkb:5-HT2_receptor
gptkb:5-HT3_receptor
gptkb:5-HT4_receptor
gptkb:5-HT5_receptor
gptkb:5-HT6_receptor
gptkb:5-HT7_receptor
|
|
gptkbp:target
|
gptkb:triptans
cancer therapies
antipsychotics
tyrosine kinase inhibitors
antidepressants
hallucinogens
|
|
gptkbp:bfsParent
|
gptkb:RET
gptkb:RET_proto-oncogene
gptkb:G_protein-coupled_receptor
gptkb:G_protein-coupled_receptors
gptkb:Lenvima
gptkb:Tasigna
|
|
gptkbp:bfsLayer
|
5
|