|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:EGFR
|
|
gptkbp:associatedWith
|
gptkb:non-small_cell_lung_cancer
gptkb:glioblastoma
colorectal cancer
head and neck cancer
|
|
gptkbp:binds
|
gptkb:amphiregulin
gptkb:betacellulin
gptkb:epidermal_growth_factor_(EGF)
gptkb:epiregulin
gptkb:transforming_growth_factor_alpha_(TGF-α)
gptkb:heparin-binding_EGF-like_growth_factor
|
|
gptkbp:domain
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:encodedBy
|
gptkb:EGFR_gene
|
|
gptkbp:Entrez_Gene_ID
|
1956
|
|
gptkbp:formsHeterodimerWith
|
gptkb:HER3
gptkb:HER4
itself
HER2
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
gptkb:Epidermal_Growth_Factor_Receptor
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
cell signaling
regulation of cell differentiation
regulation of cell proliferation
regulation of cell growth
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HER1
|
|
gptkbp:locatedOnChromosome
|
gptkb:7p11.2
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:memberOf
|
gptkb:ErbB_family
|
|
gptkbp:OMIM
|
131550
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1M17
|
|
gptkbp:phosphorylates
|
autophosphorylation upon ligand binding
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:significance
|
target for cancer therapy
overexpressed in many cancers
|
|
gptkbp:structure
|
single-pass transmembrane protein
|
|
gptkbp:target
|
gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
gptkb:panitumumab
|
|
gptkbp:UniProtID
|
gptkb:P00533
|
|
gptkbp:bfsParent
|
gptkb:EGFR
gptkb:EGFR_gene
gptkb:P15056
gptkb:P42336
gptkb:P42338
|
|
gptkbp:bfsLayer
|
6
|