Non-Small Cell Lung Cancer

URI: https://gptkb.org/entity/Non-Small_Cell_Lung_Cancer

GPTKB entity

Statements (104)

Predicate	Object
gptkbp:instanceOf	gptkb:cancer
gptkbp:5YearSurvivalRate	~25% (all stages combined)
gptkbp:abbreviation	gptkb:NSCLC
gptkbp:accountsFor	85% of lung cancer cases
gptkbp:affects	Lungs
gptkbp:canMetastasizeTo	gptkb:Brain gptkb:Bones Liver Adrenal Glands
gptkbp:clinicalTrialPhase	gptkb:CheckMate_227 gptkb:IMpower150 gptkb:KEYNOTE-024
gptkbp:diagnosedBy	Biopsy Imaging (CT, X-ray) Molecular Testing
gptkbp:firstDescribed	20th Century
gptkbp:guidanceSystem	gptkb:NCCN_Guidelines gptkb:ASCO_Guidelines gptkb:ESMO_Guidelines
gptkbp:hasApprovedDrug	gptkb:Atezolizumab gptkb:Durvalumab gptkb:Cabozantinib gptkb:Afatinib gptkb:Alectinib gptkb:Alpelisib gptkb:Amivantamab gptkb:Anlotinib gptkb:Apatinib gptkb:Bevacizumab gptkb:Brigatinib gptkb:Camrelizumab gptkb:Capmatinib gptkb:Carboplatin gptkb:Ceritinib gptkb:Cisplatin gptkb:Crizotinib gptkb:Dacomitinib gptkb:Docetaxel gptkb:Entrectinib gptkb:Erlotinib gptkb:Gefitinib gptkb:Gemcitabine gptkb:Ipilimumab gptkb:Larotrectinib gptkb:Lenvatinib gptkb:Lorlatinib gptkb:Mobocertinib gptkb:Nintedanib gptkb:Nivolumab gptkb:Osimertinib gptkb:Paclitaxel gptkb:Pembrolizumab gptkb:Pemetrexed gptkb:Pralsetinib gptkb:Ramucirumab gptkb:Regorafenib gptkb:Selpercatinib gptkb:Sintilimab gptkb:Sorafenib gptkb:Sotorasib gptkb:Tarlatamab gptkb:Tepotinib gptkb:Tislelizumab gptkb:Toripalimab gptkb:Trastuzumab_deruxtecan gptkb:Tremelimumab gptkb:Vinorelbine
gptkbp:hasBiomarker	gptkb:EGFR gptkb:KRAS gptkb:ALK gptkb:RET gptkb:BRAF gptkb:MET HER2 NTRK PD-L1 ROS1
https://www.w3.org/2000/01/rdf-schema#label	Non-Small Cell Lung Cancer
gptkbp:ICD-10_code	C34
gptkbp:mutationAssociatedWith	ALK Rearrangement EGFR Mutation KRAS Mutation
gptkbp:primaryTreatment	Radiation Therapy Surgery immunotherapy Chemotherapy Targeted Therapy
gptkbp:prognosis	Varies by stage
gptkbp:riskFactor	gptkb:Asbestos_Exposure gptkb:Radon_Exposure Smoking Family History Air Pollution
gptkbp:stagedBy	gptkb:TNM_Staging_System
gptkbp:subspecies	gptkb:cancer gptkb:Large_Cell_Carcinoma
gptkbp:symptom	Fatigue Cough Chest Pain Shortness of Breath Weight Loss
gptkbp:bfsParent	gptkb:NSCL gptkb:Squamous_Cell_Carcinoma_of_the_Lung
gptkbp:bfsLayer	5