Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
signaling molecule
|
| gptkbp:activatedBy |
stress
cytokines UV radiation inflammatory signals |
| gptkbp:alsoKnownAs |
gptkb:c-Jun_N-terminal_kinase_pathway
|
| gptkbp:cause |
phosphorylation of c-Jun
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:downstreamOf |
gptkb:ATF2
gptkb:Bcl-2_family_proteins gptkb:Elk-1 gptkb:c-Jun gptkb:p53 |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:diabetes neurodegenerative diseases inflammatory diseases |
| gptkbp:foundIn |
eukaryotes
|
| https://www.w3.org/2000/01/rdf-schema#label |
JNK pathway
|
| gptkbp:importantFor |
development
immune response cellular stress response |
| gptkbp:inhibitedBy |
gptkb:SP600125
AS601245 |
| gptkbp:involves |
gptkb:JNK_proteins
gptkb:MAPK10 gptkb:MAPK9 gptkb:MAPK8 |
| gptkbp:modulatedBy |
radiation therapy
growth factors pathogens oxidative stress DNA damage cytotoxic drugs endoplasmic reticulum stress heat shock ischemia metabolic stress osmotic shock reactive oxygen species |
| gptkbp:partOf |
MAP kinase pathways
|
| gptkbp:regulates |
apoptosis
cell differentiation cell proliferation gene expression inflammatory response |
| gptkbp:upstreamKinase |
gptkb:MKK4
gptkb:MKK7 |
| gptkbp:bfsParent |
gptkb:MAPK/ERK_pathway
|
| gptkbp:bfsLayer |
5
|