|
gptkbp:instanceOf
|
gptkb:signaling_molecule
|
|
gptkbp:activatedBy
|
stress
cytokines
UV radiation
inflammatory signals
|
|
gptkbp:alsoKnownAs
|
gptkb:c-Jun_N-terminal_kinase_pathway
|
|
gptkbp:cause
|
phosphorylation of c-Jun
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:downstreamOf
|
gptkb:ATF2
gptkb:Bcl-2_family_proteins
gptkb:Elk-1
gptkb:c-Jun
gptkb:p53
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:importantFor
|
gptkb:immune_response
gptkb:cellular_stress_response
development
|
|
gptkbp:inhibitedBy
|
gptkb:SP600125
AS601245
|
|
gptkbp:involves
|
gptkb:JNK_proteins
gptkb:MAPK10
gptkb:MAPK9
gptkb:MAPK8
|
|
gptkbp:modulatedBy
|
gptkb:radiation_therapy
gptkb:reactive_oxygen_species
growth factors
pathogens
oxidative stress
DNA damage
cytotoxic drugs
endoplasmic reticulum stress
heat shock
ischemia
metabolic stress
osmotic shock
|
|
gptkbp:partOf
|
MAP kinase pathways
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
gene expression
inflammatory response
|
|
gptkbp:upstreamKinase
|
gptkb:MKK4
gptkb:MKK7
|
|
gptkbp:bfsParent
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:bfsLayer
|
5
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JNK pathway
|