Statements (67)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
tumor suppression
|
| gptkbp:code |
p53 protein
|
| gptkbp:discovered_by |
gptkb:David_Lane
|
| gptkbp:genetic_studies |
gptkb:Oncology
sarcomas |
| gptkbp:has_role |
cell cycle regulation
cellular stress response |
| gptkbp:has_variants |
TP53 mutations
|
| https://www.w3.org/2000/01/rdf-schema#label |
TP53 gene
|
| gptkbp:interacts_with |
gptkb:MDM2
|
| gptkbp:involved_in |
apoptosis
|
| gptkbp:is_associated_with |
aging process
|
| gptkbp:is_essential_for |
genomic stability
|
| gptkbp:is_expressed_in |
most tissues
|
| gptkbp:is_involved_in |
gptkb:neurodegenerative_diseases
DNA damage response cellular homeostasis developmental processes immune response metabolic disorders autoimmune diseases wound healing cardiovascular diseases cellular proliferation cellular response to stress cellular senescence embryogenesis tumor microenvironment cellular differentiation angiogenesis chronic inflammation tissue repair viral infections metastasis cellular signaling metabolism regulation cellular response to DNA damage cellular response to cytokines cellular response to hypoxia cellular response to mechanical stress cellular response to oxidative stress cellular apoptosis cellular response to radiation cellular response to drugs cellular response to growth factors cellular response to metabolic stress cellular response to nutrient deprivation cellular response to toxins cellular response to environmental stressors cellular response to chemical stress cellular response to heat shock cellular response to hormonal signals stem cell regulation cellular response to chemokines cellular response to neurotransmitters cellular response to pathogens |
| gptkbp:is_linked_to |
gptkb:Li-Fraumeni_syndrome
|
| gptkbp:is_part_of |
tumor suppressor network
|
| gptkbp:is_regulated_by |
micro RNAs
|
| gptkbp:is_studied_in |
oncology
|
| gptkbp:is_targeted_at |
cancer therapies
|
| gptkbp:known_as |
gptkb:p53
|
| gptkbp:located_in |
chromosome 17
|
| gptkbp:regulates |
DNA repair
|
| gptkbp:bfsParent |
gptkb:TP53_mutation
|
| gptkbp:bfsLayer |
5
|