TP53 gene

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alsoKnownAs gptkb:p53
gptkb:tumor_protein_p53
gptkbp:discoveredBy gptkb:Arnold_Levine
gptkb:Lloyd_Old
gptkb:David_Lane
gptkbp:discoveredIn 1979
gptkbp:encodes gptkb:cellular_tumor_antigen_p53
gptkbp:Entrez_Gene_ID 7157
gptkbp:expressedIn most human tissues
gptkbp:function apoptosis
tumor suppressor
DNA repair
regulation of cell cycle
genomic stability
gptkbp:HGNC_ID HGNC:11998
https://www.w3.org/2000/01/rdf-schema#label TP53 gene
gptkbp:length 393 amino acids
20,000 base pairs (approximate)
gptkbp:locatedOnChromosome 17p13.1
gptkbp:mutationAssociatedWith gptkb:Li-Fraumeni_syndrome
deletion
insertion
missense mutation
various cancers
nonsense mutation
frameshift mutation
gptkbp:numberOfExons 11
gptkbp:OMIM 191170
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Trp53
gptkbp:product gptkb:p53_protein
gptkbp:proteinFamily DNA-binding domain
oligomerization domain
transactivation domain
gptkbp:regulates cell differentiation
metabolism
cellular senescence
angiogenesis
senescence
cellular metabolism
DNA damage response
autophagy
cell cycle arrest
cellular response to stress
transcription of target genes
gptkbp:significance target for cancer therapy
biomarker for cancer prognosis
gptkbp:UniProtID P04637
gptkbp:bfsParent gptkb:TP53_mutation
gptkb:NP_005017.2
gptkb:Li-Fraumeni_syndrome
gptkb:p53
gptkbp:bfsLayer 6