|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:p53
gptkb:tumor_protein_p53
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_Levine
gptkb:Lloyd_Old
gptkb:David_Lane
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:encodes
|
gptkb:cellular_tumor_antigen_p53
|
|
gptkbp:Entrez_Gene_ID
|
7157
|
|
gptkbp:expressedIn
|
most human tissues
|
|
gptkbp:function
|
gptkb:tumor_suppressor
apoptosis
DNA repair
regulation of cell cycle
genomic stability
|
|
gptkbp:HGNC_ID
|
HGNC:11998
|
|
gptkbp:length
|
393 amino acids
20,000 base pairs (approximate)
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Li-Fraumeni_syndrome
deletion
insertion
missense mutation
various cancers
nonsense mutation
frameshift mutation
|
|
gptkbp:numberOfExons
|
11
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Trp53
|
|
gptkbp:product
|
gptkb:p53_protein
|
|
gptkbp:proteinFamily
|
DNA-binding domain
oligomerization domain
transactivation domain
|
|
gptkbp:regulates
|
cell differentiation
metabolism
cellular senescence
angiogenesis
senescence
cellular metabolism
DNA damage response
autophagy
cell cycle arrest
cellular response to stress
transcription of target genes
|
|
gptkbp:significance
|
target for cancer therapy
biomarker for cancer prognosis
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:TP53_mutation
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TP53 gene
|