|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:Sestrin-1
PA26
Hi95
|
|
gptkbp:associatedWith
|
gptkb:SESN3
gptkb:cancer
gptkb:SESN2
metabolic disorders
|
|
gptkbp:discoveredBy
|
Ishihara et al.
|
|
gptkbp:discoveredIn
|
2002
|
|
gptkbp:encodes
|
gptkb:Sestrin-1_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000101347
54840
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Sestrin_1
|
|
gptkbp:function
|
antioxidant activity
regulation of mTOR signaling
negative regulation of cell growth
regulation of cellular response to stress
|
|
gptkbp:gene
|
gptkb:SESN1
|
|
gptkbp:GO_term
|
GO:0008285 (negative regulation of cell proliferation)
GO:0006979 (response to oxidative stress)
GO:0032007 (negative regulation of TOR signaling)
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:21057
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SESN1
|
|
gptkbp:interactsWith
|
gptkb:GATOR2_complex
gptkb:AMPK
gptkb:mTORC1
gptkb:p53
|
|
gptkbp:length
|
491 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:6q21
6
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Drosophila_dSesn
gptkb:mouse_Sestrin1
gptkb:rat_Sestrin1
|
|
gptkbp:proteinFamily
|
gptkb:Sestrin_family
|
|
gptkbp:regulates
|
gptkb:AMPK_signaling
gptkb:TORC1_activity
autophagy
oxidative stress response
induced by oxidative stress
regulated by p53
induced by DNA damage
|
|
gptkbp:relatedTo
|
p53 pathway
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q9Y6P5
|
|
gptkbp:bfsParent
|
gptkb:p53
|
|
gptkbp:bfsLayer
|
6
|