|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:MDM4
gptkb:murine_double_minute_4
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodedBy
|
gptkb:MDM4_gene
|
|
gptkbp:Entrez_Gene_ID
|
4194
ENSG00000198625
|
|
gptkbp:formsComplexWith
|
gptkb:MDM2
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
negative regulator of p53 tumor suppressor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MDMX
|
|
gptkbp:inhibitedBy
|
p53 transcriptional activity
|
|
gptkbp:interactsWith
|
gptkb:MDM2
gptkb:p53
|
|
gptkbp:locatedOnChromosome
|
1q32
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~54 kDa
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
|
|
gptkbp:overexpressedIn
|
various cancers
|
|
gptkbp:PDB
|
1Z1M
|
|
gptkbp:phosphorylates
|
gptkb:ATM_kinase
gptkb:CHK2
|
|
gptkbp:regulates
|
p53 stability
|
|
gptkbp:role
|
cell cycle regulation
tumorigenesis
|
|
gptkbp:target
|
anticancer drug development
|
|
gptkbp:UniProtID
|
O15151
|
|
gptkbp:bfsParent
|
gptkb:MDM2
gptkb:p53
gptkb:MIPS_instruction_set_architecture
|
|
gptkbp:bfsLayer
|
6
|