Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alsoKnownAs |
gptkb:MDM4
gptkb:murine_double_minute_4 |
| gptkbp:degradedBy |
gptkb:ubiquitin-proteasome_pathway
|
| gptkbp:discoveredIn |
1996
|
| gptkbp:encodedBy |
gptkb:MDM4_gene
|
| gptkbp:Entrez_Gene_ID |
4194
ENSG00000198625 |
| gptkbp:formsComplexWith |
gptkb:MDM2
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
negative regulator of p53 tumor suppressor
|
| gptkbp:inhibitedBy |
p53 transcriptional activity
|
| gptkbp:interactsWith |
gptkb:MDM2
gptkb:p53 |
| gptkbp:locatedOnChromosome |
1q32
|
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:molecularWeight |
~54 kDa
|
| gptkbp:orthologIn |
gptkb:Mus_musculus
|
| gptkbp:overexpressedIn |
various cancers
|
| gptkbp:PDB |
1Z1M
|
| gptkbp:phosphorylates |
gptkb:ATM_kinase
gptkb:CHK2 |
| gptkbp:regulates |
p53 stability
|
| gptkbp:role |
cell cycle regulation
tumorigenesis |
| gptkbp:target |
anticancer drug development
|
| gptkbp:UniProtID |
O15151
|
| gptkbp:bfsParent |
gptkb:MDM2
|
| gptkbp:bfsLayer |
6
|
| https://www.w3.org/2000/01/rdf-schema#label |
MDMX
|