|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:DED
gptkb:CHE-1
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:component
|
nucleolus
nucleoplasm
|
|
gptkbp:discoveredBy
|
gptkb:Fanciulli_M_et_al.
|
|
gptkbp:domain
|
nuclear localization signal
leucine zipper domain
transcriptional activation domain
|
|
gptkbp:encodes
|
gptkb:AATF_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000129515
26574
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
2000
|
|
gptkbp:fullName
|
gptkb:apoptosis_antagonizing_transcription_factor
|
|
gptkbp:function
|
regulation of apoptosis
cell cycle control
DNA binding
transcriptional regulation
transcription coactivator activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
negative regulation of apoptotic process
positive regulation of transcription by RNA polymerase II
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:191
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AATF
|
|
gptkbp:interactsWith
|
gptkb:RNA_polymerase_II
gptkb:MDM2
gptkb:p53
|
|
gptkbp:length
|
560 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
|
|
gptkbp:molecularWeight
|
62 kDa
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
|
|
gptkbp:OMIM
|
604902
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Aatf
|
|
gptkbp:phosphorylates
|
gptkb:ATM_kinase
gptkb:ATR_kinase
|
|
gptkbp:RefSeq
|
gptkb:NM_015285
|
|
gptkbp:regulates
|
cell proliferation
cell survival
DNA damage response
cell cycle arrest
p53-mediated transcription
apoptosis in response to DNA damage
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
nucleolus
|
|
gptkbp:UniProtID
|
gptkb:Q9NY61
|
|
gptkbp:bfsParent
|
gptkb:African_Agricultural_Technology_Foundation
|
|
gptkbp:bfsLayer
|
5
|