|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:MIC-1
gptkb:NAG-1
gptkb:PLAB
PDF
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
metabolic disorders
|
|
gptkbp:discoveredBy
|
gptkb:Hromas_et_al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000130513
9518
|
|
gptkbp:expressedIn
|
gptkb:kidney
gptkb:placenta
gptkb:prostate
liver
macrophages
|
|
gptkbp:family
|
gptkb:TGF-beta_superfamily
|
|
gptkbp:fullName
|
gptkb:Growth_Differentiation_Factor_15
|
|
gptkbp:function
|
cellular response to stress
regulation of inflammatory and apoptotic pathways
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasBiomarker
|
heart failure
prostate cancer
cachexia
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:14046
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GDF15
|
|
gptkbp:inducedBy
|
inflammation
cellular stress
|
|
gptkbp:length
|
308 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.11
19
plus
|
|
gptkbp:molecularWeight
|
35 kDa
|
|
gptkbp:OMIM
|
605312
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Gdf15
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic cleavage
|
|
gptkbp:recipient
|
gptkb:GFRAL
|
|
gptkbp:regulates
|
appetite
inflammatory response
body weight
energy homeostasis
|
|
gptkbp:secretes
|
yes
|
|
gptkbp:UniProtID
|
gptkb:Q99988
|
|
gptkbp:bfsParent
|
gptkb:p53
|
|
gptkbp:bfsLayer
|
6
|