|
gptkbp:instanceOf
|
signaling molecule
|
|
gptkbp:activatedBy
|
gptkb:IL-1
gptkb:TNF-alpha
UV radiation
environmental stress
heat shock
lipopolysaccharide
osmotic shock
pro-inflammatory cytokines
|
|
gptkbp:component
|
gptkb:MAP2K3
gptkb:MAP2K6
gptkb:MAPK11
gptkb:MAPK12
gptkb:MAPK13
gptkb:MAPK14
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:downstreamOf
|
gptkb:ATF2
gptkb:ELK1
gptkb:MEF2C
gptkb:p53
transcription factors
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p38 MAPK pathway
|
|
gptkbp:inhibitedBy
|
gptkb:BIRB796
gptkb:SB203580
|
|
gptkbp:involves
|
gptkb:p38_mitogen-activated_protein_kinases
|
|
gptkbp:modulatedBy
|
cell proliferation
cell migration
cytokine production
|
|
gptkbp:phosphorylates
|
gptkb:CREB
gptkb:HSP27
gptkb:MAPKAPK2
gptkb:MAPKAPK3
gptkb:MAPKAPK5
gptkb:MNK1
gptkb:MSK1
gptkb:Rsk
gptkb:STAT1
|
|
gptkbp:regulates
|
cell differentiation
cell cycle
inflammatory response
cell apoptosis
|
|
gptkbp:relatedTo
|
gptkb:ERK_pathway
gptkb:JNK_pathway
gptkb:MAPK_signaling_pathway
|
|
gptkbp:studiedIn
|
gptkb:cancer
neurodegenerative diseases
cardiovascular diseases
autoimmune diseases
|
|
gptkbp:upregulatedBy
|
gptkb:MKK3
gptkb:MKK6
gptkb:TAK1
ASK1
|
|
gptkbp:bfsParent
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:bfsLayer
|
5
|