|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
1989
|
|
gptkbp:encodedBy
|
gptkb:IGFBP3_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000146674
|
|
gptkbp:expressedIn
|
gptkb:plasma
liver
various tissues
|
|
gptkbp:fullName
|
gptkb:Insulin-like_growth_factor-binding_protein_3
|
|
gptkbp:function
|
induces apoptosis
binds insulin-like growth factors
modulates cell growth
regulates IGF availability
|
|
gptkbp:gene
|
gptkb:IGFBP3
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:5464
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IGFBP3
|
|
gptkbp:interactsWith
|
gptkb:IGF1
gptkb:acid-labile_subunit_(ALS)
gptkb:IGF2
|
|
gptkbp:length
|
291 amino acids
|
|
gptkbp:locatedOnChromosome
|
7p13-p12
|
|
gptkbp:molecularWeight
|
~28-40 kDa
|
|
gptkbp:OMIM
|
146732
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:1BOE
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:RefSeq
|
gptkb:NP_000588
|
|
gptkbp:significance
|
associated with growth disorders
biomarker in cancer
|
|
gptkbp:UniProtID
|
P17936
|
|
gptkbp:bfsParent
|
gptkb:p53
|
|
gptkbp:bfsLayer
|
6
|