|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:Sestrin-2
PA26
Hi95
|
|
gptkbp:associatedWith
|
gptkb:cancer
aging
metabolic disorders
|
|
gptkbp:discoveredBy
|
2002
|
|
gptkbp:encodedBy
|
gptkb:SESN2_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000168137
83667
|
|
gptkbp:expressedIn
|
ubiquitous
high in heart
high in liver
high in skeletal muscle
|
|
gptkbp:fullName
|
gptkb:Sestrin_2
|
|
gptkbp:function
|
antioxidant activity
regulation of mTOR signaling pathway
regulation of cellular response to stress
|
|
gptkbp:gene
|
gptkb:SESN2
|
|
gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SESN2
|
|
gptkbp:inducedBy
|
gptkb:p53
|
|
gptkbp:interactsWith
|
gptkb:GATOR2_complex
gptkb:AMPK
gptkb:mTORC1
|
|
gptkbp:involves
|
autophagy
metabolic homeostasis
protection against oxidative damage
|
|
gptkbp:length
|
480 amino acids
|
|
gptkbp:locatedOnChromosome
|
1p35.3
|
|
gptkbp:molecularWeight
|
57 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Sestrin2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
regulated by p53
AMPK activity
upregulated by oxidative stress
mTORC1 activity
upregulated by DNA damage
|
|
gptkbp:relatedTo
|
cellular senescence
DNA damage response
oxidative stress
|
|
gptkbp:structure
|
contains Sestrin domain
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q9Y6P5
|
|
gptkbp:bfsParent
|
gptkb:p53
|
|
gptkbp:bfsLayer
|
6
|