|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:Ki-ras
gptkb:RASK2
gptkb:c-K-ras
gptkb:K-Ras2A
gptkb:NS_(neuroblastoma_ras_viral_oncogene_homolog)
|
|
gptkbp:associatedWith
|
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Noonan_syndrome
gptkb:RASopathies
Leukemia
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodes
|
gptkb:KRAS_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000133703
3845
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:function
|
guanine nucleotide exchange factor
signal transduction
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasParalog
|
gptkb:HRAS_(human)
gptkb:NRAS_(human)
|
|
gptkbp:hasTranscriptVariant
|
gptkb:KRAS4A
gptkb:KRAS4B
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KRAS (human)
|
|
gptkbp:interactsWith
|
gptkb:GAPs
gptkb:GEFs
gptkb:NF1
gptkb:RASA1
gptkb:BRAF
gptkb:GRB2
gptkb:PIK3CA
gptkb:RAF1
gptkb:SOS1
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
cell differentiation
cell proliferation
apoptosis regulation
|
|
gptkbp:length
|
6 exons
|
|
gptkbp:locatedOnChromosome
|
12
12p12.1
|
|
gptkbp:memberOf
|
gptkb:RAS_gene_family
tumor suppressor
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:G12V
gptkb:G13D
gptkb:Q61H
gptkb:endometrial_cancer
colorectal cancer
pancreatic cancer
G12D
bladder cancer
missense mutation
point mutation
|
|
gptkbp:OMIM
|
190070
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:KRAS_(mouse)
gptkb:KRAS_(rat)
|
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
gptkb:EGFR_signaling_pathway
gptkb:Ras_signaling_pathway
gptkb:Wnt_signaling_pathway
gptkb:ErbB_signaling_pathway
gptkb:Focal_adhesion_pathway
gptkb:FoxO_signaling_pathway
gptkb:Rap1_signaling_pathway
Regulation of actin cytoskeleton
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
phosphorylation
|
|
gptkbp:product
|
gptkb:KRAS_protein
|
|
gptkbp:proteinFamily
|
small molecule
tumor suppressor
|
|
gptkbp:RefSeq
|
NM_004985
|
|
gptkbp:regulates
|
cell survival
cell growth
cell migration
|
|
gptkbp:significance
|
biomarker for targeted therapy
prognostic marker in cancer
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
endomembrane system
|
|
gptkbp:target
|
gptkb:adagrasib
gptkb:sotorasib
gptkb:AMG_510
gptkb:MRTX849
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:c-K-ras
|
|
gptkbp:bfsLayer
|
6
|