|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:p21ras
gptkb:C-H-RAS
gptkb:HRAS1
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Costello_syndrome
gptkb:head_and_neck_squamous_cell_carcinoma
bladder cancer
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:encodes
|
gptkb:GTPase_HRas
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000174775
3265
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:firstDescribed
|
1982
|
|
gptkbp:function
|
signal transduction
GTP binding
GTPase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
gptkb:NM_005343
gptkb:NM_176795
|
|
gptkbp:HGNC_ID
|
5173
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HRAS (human)
|
|
gptkbp:interactsWith
|
gptkb:NF1
gptkb:RAP1A
gptkb:RASA1
gptkb:RIN1
gptkb:BRAF
gptkb:GRB2
gptkb:PIK3CA
gptkb:RAF1
gptkb:SOS1
|
|
gptkbp:length
|
approximately 3.8 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
chromosome 11
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
codon 12
codon 13
codon 61
oncogenic mutation
|
|
gptkbp:OMIM
|
190020
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:HRAS_(mouse)
gptkb:HRAS_(rat)
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:proteinFamily
|
gptkb:Ras_family
GTPase domain
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:Hras1
|
|
gptkbp:bfsLayer
|
6
|