MRTX849

GPTKB entity

Statements (29)
Predicate Object
gptkbp:instanceOf gptkb:drug
KRAS inhibitor
gptkbp:alsoKnownAs gptkb:adagrasib
gptkbp:approvedBy 2022
gptkbp:ATCCode L01EG04
gptkbp:CASNumber 2389149-74-5
gptkbp:clinicalTrialPhase Phase 2
gptkbp:developedBy gptkb:Mirati_Therapeutics
gptkbp:hasInChIKey QZJXODQKZQJZQJ-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C32H35ClFN7O2
gptkbp:hasSMILES CC1=CC2=C(C=C1)N=C(N2)N3CCN(CC3)C(=O)C4=CC=C(C=C4)Cl
https://www.w3.org/2000/01/rdf-schema#label MRTX849
gptkbp:indication gptkb:non-small_cell_lung_cancer
colorectal cancer
gptkbp:mechanismOfAction covalent inhibitor of KRAS G12C
gptkbp:molecularWeight 604.1 g/mol
gptkbp:PubChem_CID 134584744
CHEMBL4297597
gptkbp:regulates approved
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
vomiting
diarrhea
fatigue
liver enzyme elevation
gptkbp:target KRAS G12C mutation
gptkbp:UNII 6Q1K1VJ0Z1
gptkbp:bfsParent gptkb:KRAS_(human)
gptkbp:bfsLayer 7