|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeTo
|
gptkb:NRAS
gptkb:CMNS
gptkb:NCMS
NS6
|
|
gptkbp:associatedWith
|
gptkb:acute_myeloid_leukemia
colorectal cancer
melanoma
Noonan syndrome 6
|
|
gptkbp:chromosomeArm
|
1p13.2
|
|
gptkbp:discoveredBy
|
gptkb:Robin_Weiss
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:encodes
|
gptkb:NRAS_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000213281
4893
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:neuroblastoma_RAS_viral_oncogene_homolog
|
|
gptkbp:function
|
guanine nucleotide exchange factor
signal transduction
|
|
gptkbp:gene_ontology_(biological_process)
|
signal transduction
|
|
gptkbp:gene_ontology_(cellular_component)
|
gptkb:plasma_membrane
|
|
gptkbp:gene_ontology_(molecular_function)
|
GTP binding
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
7989
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NRAS (human)
|
|
gptkbp:length
|
189
|
|
gptkbp:locatedOnChromosome
|
1
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutation_hotspot
|
codon 12
codon 13
codon 61
|
|
gptkbp:mutationAssociatedWith
|
oncogenic
constitutive activation of signaling pathways
|
|
gptkbp:OMIM
|
164790
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Nras
|
|
gptkbp:orthologInZebrafish
|
nras
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:product
|
gptkb:NRAS_protein
|
|
gptkbp:proteinFamily
|
gptkb:RAS_family
gptkb:GTP-binding_domain
|
|
gptkbp:reference_sequence_(protein)
|
NP_002515
|
|
gptkbp:reference_sequence_(RefSeq)
|
gptkb:NM_002524
|
|
gptkbp:regulates
|
regulated by GEFs and GAPs
|
|
gptkbp:significance
|
target for cancer therapy
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:P01111
|
|
gptkbp:bfsParent
|
gptkb:KRAS_(human)
|
|
gptkbp:bfsLayer
|
7
|