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gptkbp:instanceOf
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biological pathway
|
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gptkbp:activatedBy
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gptkb:R-spondin
gptkb:Wnt_ligands
|
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gptkbp:alsoKnownAs
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gptkb:Wnt_pathway
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gptkbp:dysregulationAssociatedWith
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gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:bone
colorectal cancer
|
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gptkbp:firstDescribed
|
1982
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gptkbp:hasComponent
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gptkb:β-catenin_destruction_complex
gptkb:Axin
gptkb:Dishevelled
gptkb:Frizzled/LRP5/6_receptor_complex
gptkb:GSK-3β
gptkb:TCF/LEF
gptkb:Wnt_ligands
gptkb:APC
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Wnt signaling pathway
|
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gptkbp:importantFor
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axis patterning
bone formation
neurogenesis
stem cell maintenance
tissue regeneration
|
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gptkbp:inhibitedBy
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gptkb:LGK974
tankyrase inhibitors
|
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gptkbp:involves
|
gptkb:APC_protein
gptkb:Axin
gptkb:Dishevelled_proteins
gptkb:Frizzled_receptors
gptkb:GSK-3β
gptkb:TCF/LEF_transcription_factors
gptkb:Wnt_proteins
gptkb:β-catenin
|
|
gptkbp:modulatedBy
|
gptkb:R-spondin_proteins
gptkb:sFRP_proteins
gptkb:DKK1
gptkb:WIF1
Porcupine enzyme
|
|
gptkbp:namedAfter
|
Wingless (Drosophila) and Int-1 (mouse)
|
|
gptkbp:regulates
|
cell proliferation
embryonic development
cell migration
cell fate determination
|
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gptkbp:studiedIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Drosophila_melanogaster
|
|
gptkbp:subspecies
|
canonical Wnt pathway
non-canonical Wnt pathway
|
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gptkbp:bfsParent
|
gptkb:KRAS
gptkb:CTNNB1
|
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gptkbp:bfsLayer
|
5
|