|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors
|
|
gptkbp:alias
|
gptkb:K-Ras
gptkb:Ki-Ras
gptkb:V-Ki-ras2_Kirsten_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:decommissioned
|
GTPase-activating proteins
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:KRAS_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000133703
3845
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:hasIsoform
|
gptkb:KRAS4A
gptkb:KRAS4B
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KRAS protein
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
cell signaling
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
|
|
gptkbp:memberOf
|
gptkb:RAS_family
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:G12V
gptkb:G13D
gptkb:Q61H
colorectal cancer
pancreatic cancer
G12D
G12C
|
|
gptkbp:OMIM
|
190070
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
6GJ8
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:RefSeq
|
gptkb:NP_004976
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:subcellularLocation
|
gptkb:plasma_membrane
|
|
gptkbp:target
|
gptkb:adagrasib
gptkb:sotorasib
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:KRAS
|
|
gptkbp:bfsLayer
|
5
|