Kirsten rat sarcoma viral oncogene homolog

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:gene
gptkbp:abbreviation	gptkb:KRAS
gptkbp:alternativeName	gptkb:K-Ras gptkb:v-Ki-ras2_Kirsten_rat_sarcoma_viral_oncogene_homolog gptkb:c-K-ras
gptkbp:associatedWith	gptkb:cancer colorectal cancer pancreatic cancer
gptkbp:discoveredIn	1982
gptkbp:encodes	gptkb:KRAS_protein
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000133703 3845
gptkbp:expressedIn	many tissues
gptkbp:firstDescribed	gptkb:Der,_C.J. gptkb:Weinberg,_R.A. gptkb:Nature_journal 1982
gptkbp:function	GTPase activity
gptkbp:HGNC_ID	gptkb:HGNC:6407
gptkbp:length	189 amino acids
gptkbp:locatedOnChromosome	gptkb:chromosome_12
gptkbp:memberOf	gptkb:RAS_gene_family
gptkbp:mutationAssociatedWith	codon 12 codon 13 codon 61 oncogenic mutation
gptkbp:OMIM	190070
gptkbp:orthologIn	gptkb:mouse gptkb:right gptkb:zebrafish
gptkbp:pathway	gptkb:MAPK/ERK_pathway gptkb:PI3K/AKT_pathway
gptkbp:product	gptkb:small_molecule
gptkbp:proteinFamily	gptkb:RAS_superfamily
gptkbp:regulates	apoptosis cell differentiation cell proliferation cell survival
gptkbp:symbol	gptkb:KRAS
gptkbp:targetOfDrug	gptkb:adagrasib gptkb:sotorasib
gptkbp:UniProtID	gptkb:P01116
gptkbp:bfsParent	gptkb:KRAS
gptkbp:bfsLayer	5
https://www.w3.org/2000/01/rdf-schema#label	Kirsten rat sarcoma viral oncogene homolog