Kirsten rat sarcoma viral oncogene homolog

URI: https://gptkb.org/entity/Kirsten_rat_sarcoma_viral_oncogene_homolog
GPTKB entity
Statements (45)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:abbreviation gptkb:KRAS
gptkbp:alternativeName gptkb:K-Ras
gptkb:v-Ki-ras2_Kirsten_rat_sarcoma_viral_oncogene_homolog
gptkb:c-K-ras
gptkbp:associatedWith gptkb:cancer
colorectal cancer
pancreatic cancer
gptkbp:discoveredIn 1982
gptkbp:encodes gptkb:KRAS_protein
gptkbp:Entrez_Gene_ID gptkb:ENSG00000133703
3845
gptkbp:expressedIn many tissues
gptkbp:firstDescribed gptkb:Der,_C.J.
gptkb:Weinberg,_R.A.
gptkb:Nature_journal
1982
gptkbp:function GTPase activity
gptkbp:HGNC_ID gptkb:HGNC:6407
https://www.w3.org/2000/01/rdf-schema#label Kirsten rat sarcoma viral oncogene homolog
gptkbp:length 189 amino acids
gptkbp:locatedOnChromosome gptkb:chromosome_12
gptkbp:memberOf gptkb:RAS_gene_family
gptkbp:mutationAssociatedWith codon 12
codon 13
codon 61
oncogenic mutation
gptkbp:OMIM 190070
gptkbp:orthologIn gptkb:mouse
gptkb:zebrafish
right
gptkbp:pathway gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkbp:product small molecule
gptkbp:proteinFamily gptkb:RAS_superfamily
gptkbp:regulates apoptosis
cell differentiation
cell proliferation
cell survival
gptkbp:symbol gptkb:KRAS
gptkbp:targetOfDrug gptkb:adagrasib
gptkb:sotorasib
gptkbp:UniProtID gptkb:P01116
gptkbp:bfsParent gptkb:KRAS
gptkbp:bfsLayer 5