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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:Guanine_exchange_factors
gptkb:Guanine_nucleotide_releasing_factors
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gptkbp:category
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enzymes
cell signaling proteins
regulatory proteins
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gptkbp:dysregulationAssociatedWith
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gptkb:cancer
neurological disorders
immune diseases
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gptkbp:example
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gptkb:C3G
gptkb:Dbl
gptkb:Dock180
gptkb:Epac
gptkb:RAPGEF1
gptkb:RAPGEF2
gptkb:RAPGEF3
gptkb:RAPGEF4
gptkb:RAPGEF5
gptkb:RAPGEF6
gptkb:RasGRP
gptkb:Tiam1
gptkb:Vav1
gptkb:piano
gptkb:BRAG1
gptkb:BRAG_family
gptkb:DOCK_family
gptkb:Dbl_family
gptkb:EFA6
gptkb:EFA6_family
gptkb:Epac_family
gptkb:GEF-H1
gptkb:GEF-H1_family
gptkb:Kalirin
gptkb:Kalirin_family
gptkb:MADD
gptkb:MADD_family
gptkb:RAPGEF_family
gptkb:RCC1
gptkb:RCC1_family
gptkb:RasGRF1
gptkb:RasGRF2
gptkb:RasGRF_family
gptkb:RasGRP1
gptkb:RasGRP2
gptkb:RasGRP3
gptkb:RasGRP4
gptkb:RasGRP_family
gptkb:Rex1
gptkb:Rex_family
gptkb:Sec7_domain_family
gptkb:Tiam_family
gptkb:Trio_family
gptkb:Vav_family
gptkb:SOS1
Intersectin
Intersectin family
Sec7 domain GEFs
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gptkbp:foundIn
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eukaryotic cells
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gptkbp:fullName
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Guanine nucleotide exchange factors
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gptkbp:function
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activate monomeric GTPases
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https://www.w3.org/2000/01/rdf-schema#label
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GEFs
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gptkbp:mechanismOfAction
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facilitate exchange of GDP for GTP
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gptkbp:regulates
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cell differentiation
vesicle trafficking
cell growth
cell migration
cell signaling pathways
cytoskeletal organization
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gptkbp:target
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Arf family GTPases
Rab family GTPases
Ras family GTPases
Rho family GTPases
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gptkbp:bfsParent
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gptkb:GTPase_HRas
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gptkbp:bfsLayer
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6
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