Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
guanine nucleotide exchange factors (GEFs)
|
| gptkbp:associatedWith |
gptkb:cancer
|
| gptkbp:contains |
gptkb:GTP-binding_domain
|
| gptkbp:decommissioned |
GTPase-activating proteins (GAPs)
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:encodes |
gptkb:Ras_proteins
|
| gptkbp:foundIn |
animals
humans |
| gptkbp:function |
signal transduction
|
| https://www.w3.org/2000/01/rdf-schema#label |
RAS gene family
|
| gptkbp:includes |
gptkb:HRAS
gptkb:KRAS gptkb:NRAS |
| gptkbp:locatedOnChromosome |
HRAS: 11p15.5
KRAS: 12p12.1 NRAS: 1p13.2 |
| gptkbp:memberOf |
gptkb:small_GTPase_superfamily
|
| gptkbp:mutationAssociatedWith |
oncogenic transformation
|
| gptkbp:mutationCommonIn |
gptkb:cancer
colorectal cancer pancreatic cancer |
| gptkbp:namedAfter |
gptkb:rat_sarcoma_virus
|
| gptkbp:regulates |
cell differentiation
cell proliferation cell survival |
| gptkbp:bfsParent |
gptkb:HRAS
gptkb:NRAS gptkb:RAS_gene |
| gptkbp:bfsLayer |
5
|