ULK1

URI: https://gptkb.org/entity/ULK1
GPTKB entity
Statements (36)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alternativeName gptkb:ATG1
gptkb:Unc-51-like_kinase_1
gptkbp:Entrez_Gene_ID gptkb:ENSG00000177169
8408
gptkbp:expressedIn various tissues
gptkbp:fullName gptkb:Unc-51_Like_Autophagy_Activating_Kinase_1
gptkbp:function autophagy regulation
serine/threonine kinase activity
gptkbp:GO_term GO:0006914 (autophagy)
GO:0004674 (protein serine/threonine kinase activity)
gptkbp:HGNC_ID gptkb:HGNC:12558
https://www.w3.org/2000/01/rdf-schema#label ULK1
gptkbp:inhibitedBy gptkb:mTORC1
gptkbp:interactsWith gptkb:ATG101
gptkb:ATG13
gptkb:FIP200
gptkbp:locatedOnChromosome gptkb:12q24.33
chromosome 12: 122,397,241-122,448,040 (GRCh38)
gptkbp:mutationAssociatedWith gptkb:cancer
neurodegenerative diseases
gptkbp:OMIM 607034
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:C._elegans_unc-51
gptkbp:pathway gptkb:mTOR_signaling_pathway
autophagy
gptkbp:PDB gptkb:4WNP
gptkbp:phosphorylates gptkb:AMPK
gptkbp:species gptkb:human
gptkbp:UniProtID gptkb:O75385
gptkbp:bfsParent gptkb:AMPK_pathway
gptkb:mechanistic_target_of_rapamycin_pathway
gptkb:mTOR
gptkb:mTORC1
gptkbp:bfsLayer 6