|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:glucagon
|
|
gptkbp:alsoKnownAs
|
gptkb:TORC2
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
|
|
gptkbp:domain
|
transactivation domain
coiled-coil domain
CREB-binding domain
|
|
gptkbp:encodedBy
|
CRTC2 gene
|
|
gptkbp:Entrez_Gene_ID
|
64764
ENSG00000163466
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
pancreas
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
CREB regulated transcription coactivator 2
|
|
gptkbp:function
|
transcription coactivator
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:21013
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CRTC2
|
|
gptkbp:inhibitedBy
|
gptkb:insulin
|
|
gptkbp:involvedIn
|
energy metabolism
gluconeogenesis
|
|
gptkbp:length
|
693 amino acids
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
1q21.3
|
|
gptkbp:modulatedBy
|
insulin signaling
|
|
gptkbp:molecularWeight
|
73 kDa
|
|
gptkbp:OMIM
|
611613
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:phosphorylates
|
gptkb:AMPK
gptkb:Ser171
Ser307
Ser587
SIK1
Ser275
Ser370
|
|
gptkbp:regulates
|
lipid metabolism
neuronal plasticity
circadian rhythm
memory formation
hepatic glucose production
fasting response
CREB-mediated transcription
PGC-1alpha expression
gluconeogenic genes
|
|
gptkbp:UniProtID
|
Q53ET0
|
|
gptkbp:bfsParent
|
gptkb:AMPK_pathway
|
|
gptkbp:bfsLayer
|
6
|