Statements (61)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
transcription factor |
| gptkbp:activatedBy |
phytochemicals
oxidative stress electrophiles |
| gptkbp:binds |
antioxidant response element (ARE)
|
| gptkbp:discoveredBy |
gptkb:Masayuki_Yamamoto
|
| gptkbp:discoveredIn |
1994
|
| gptkbp:encodedBy |
NFE2L2 gene
|
| gptkbp:fullName |
Nuclear factor erythroid 2-related factor 2
|
| gptkbp:function |
regulates cellular response to stress
protects against oxidative damage regulates expression of antioxidant proteins |
| gptkbp:gene |
NFE2L2
|
| https://www.w3.org/2000/01/rdf-schema#label |
Nrf2
|
| gptkbp:inhibitedBy |
KEAP1
|
| gptkbp:interactsWith |
KEAP1
|
| gptkbp:locatedOnChromosome |
2q31.2
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:regulates |
apoptosis
cell proliferation lipid metabolism mitochondrial function immune response metabolic pathways autophagy iron metabolism inflammatory response drug metabolism fibrosis proteasome activity NAD(P)H quinone oxidoreductase 1 (NQO1) cellular redox homeostasis glutathione S-transferase heme oxygenase-1 (HO-1) phase II detoxifying enzymes |
| gptkbp:role |
gptkb:cancer
neurodegenerative diseases cardiovascular diseases inflammatory diseases |
| gptkbp:subcellularLocation |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:target |
gptkb:CAPE
gptkb:dimethyl_fumarate gptkb:EGCG sulforaphane quercetin resveratrol curcumin luteolin oleanolic acid CDDO-Me EGCG (epigallocatechin gallate) bardoxolone methyl bardoxolone methyl (CDDO-Me) caffeic acid phenethyl ester (CAPE) dimethyl fumarate (Tecfidera) tBHQ (tert-butylhydroquinone) |
| gptkbp:UniProtID |
Q16236
|
| gptkbp:bfsParent |
gptkb:AMPK_pathway
|
| gptkbp:bfsLayer |
6
|