|
gptkbp:instanceOf
|
gptkb:protein
transcription factor
|
|
gptkbp:activatedBy
|
gptkb:insulin
gptkb:liver_X_receptor_(LXR)
|
|
gptkbp:alternativeName
|
gptkb:SREBP1c
gptkb:sterol_regulatory_element-binding_protein_1c
|
|
gptkbp:alternativeSplicing
|
gptkb:SREBF1_gene
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
gptkb:non-alcoholic_fatty_liver_disease_(NAFLD)
obesity
insulin resistance
|
|
gptkbp:cleavage
|
gptkb:site-1_protease_(S1P)
gptkb:site-2_protease_(S2P)
|
|
gptkbp:discoveredBy
|
gptkb:Brown_and_Goldstein_lab
|
|
gptkbp:encodedBy
|
gptkb:SREBF1_gene
|
|
gptkbp:expressedIn
|
liver
adipose tissue
|
|
gptkbp:firstDescribed
|
1993
|
|
gptkbp:function
|
activates genes involved in fatty acid biosynthesis
activates genes involved in triglyceride biosynthesis
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SREBP-1c
|
|
gptkbp:inhibitedBy
|
gptkb:AMPK
polyunsaturated fatty acids
|
|
gptkbp:locale
|
gptkb:endoplasmic_reticulum
gptkb:nucleus
|
|
gptkbp:memberOf
|
gptkb:SREBP_family
|
|
gptkbp:regulates
|
gptkb:ATP_citrate_lyase_(ACLY)
gptkb:acetyl-CoA_carboxylase_(ACC)
gptkb:elongation_of_very_long_chain_fatty_acids_protein_6_(ELOVL6)
gptkb:fatty_acid_synthase_(FASN)
gptkb:glucose-6-phosphate_dehydrogenase_(G6PD)
gptkb:glycerol-3-phosphate_acyltransferase_(GPAT)
gptkb:malic_enzyme_(ME1)
gptkb:stearoyl-CoA_desaturase-1_(SCD1)
cholesterol metabolism
fatty acid synthesis
lipogenesis
hepatic steatosis
NADPH production
lipid homeostasis
lipogenic gene expression
triglyceride synthesis
|
|
gptkbp:relatedTo
|
gptkb:SREBP-1a
gptkb:SREBP-2
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:translocatesTo
|
nucleus after cleavage
|
|
gptkbp:UniProtID
|
gptkb:P36956-2
|
|
gptkbp:bfsParent
|
gptkb:AMPK_pathway
gptkb:LXR
|
|
gptkbp:bfsLayer
|
6
|