|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:HMG-CoA_reductase
gptkb:HMGCR1
gptkb:LDLCQ3
statin target
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:familial_hypercholesterolemia
|
|
gptkbp:biologicalProcess
|
lipid metabolic process
sterol biosynthetic process
|
|
gptkbp:encodes
|
gptkb:HMG-CoA_reductase
|
|
gptkbp:Entrez_Gene_ID
|
3156
|
|
gptkbp:enzymeCommissionNumber
|
1.1.1.34
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
liver
|
|
gptkbp:fullName
|
gptkb:3-hydroxy-3-methylglutaryl-CoA_reductase
|
|
gptkbp:function
|
oxidoreductase activity
catalyzes conversion of HMG-CoA to mevalonate
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOCellularComponent
|
gptkb:endoplasmic_reticulum
integral component of membrane
|
|
gptkbp:GOMolecularFunction
|
catalytic activity
HMG-CoA reductase activity
NADPH binding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
5006
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HMGCR
|
|
gptkbp:length
|
888 amino acids
|
|
gptkbp:locatedOnChromosome
|
5q13.3-q14
|
|
gptkbp:molecularWeight
|
97 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:statin-induced_myopathy
mevalonic aciduria
|
|
gptkbp:OMIM
|
142910
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Hmgcr
|
|
gptkbp:pathway
|
cholesterol biosynthesis
|
|
gptkbp:PDB
|
gptkb:1HWK
|
|
gptkbp:regulates
|
regulated by SREBP
feedback inhibited by cholesterol
|
|
gptkbp:subcellularLocation
|
endoplasmic reticulum membrane
|
|
gptkbp:target
|
statins
|
|
gptkbp:UniProtID
|
P04035
|
|
gptkbp:bfsParent
|
gptkb:AMPK_pathway
|
|
gptkbp:bfsLayer
|
6
|