|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:PPARGC1A
PGC1-alpha
PGC1α
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
gptkb:Bruce_Spiegelman
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:downregulatedIn
|
gptkb:type_2_diabetes
obesity
|
|
gptkbp:encodedBy
|
PPARGC1A gene
|
|
gptkbp:expressedIn
|
gptkb:brown_adipose_tissue
gptkb:skeletal_muscle
heart
liver
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
|
|
gptkbp:function
|
mitochondrial biogenesis
regulation of glucose metabolism
regulation of fatty acid oxidation
regulation of energy metabolism
transcriptional coactivator
adaptive thermogenesis
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PGC-1α
|
|
gptkbp:interactsWith
|
gptkb:CREB
PPARγ
ERRα
NRF1
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
4p15.1
|
|
gptkbp:phosphorylates
|
gptkb:p38_MAPK
gptkb:AMPK
|
|
gptkbp:regulates
|
gptkb:GLUT4
gptkb:TFAM
CPT1B
NRF2
UCP1
mitochondrial DNA transcription
|
|
gptkbp:relatedTo
|
neurodegenerative diseases
cardiovascular diseases
muscle atrophy
mitochondrial diseases
|
|
gptkbp:UniProtID
|
Q9UBK2
|
|
gptkbp:upregulatedBy
|
fasting
exercise
cold exposure
|
|
gptkbp:bfsParent
|
gptkb:AMPK_pathway
|
|
gptkbp:bfsLayer
|
6
|