AMPK (AMP-activated protein kinase)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:activatedBy	gptkb:AICAR gptkb:metformin gptkb:AMP gptkb:ADP exercise caloric restriction
gptkbp:catalyzes	alpha subunit
gptkbp:composedOf	alpha subunit beta subunit gamma subunit
gptkbp:discoveredBy	gptkb:D._Grahame_Hardie
gptkbp:EC_number	2.7.11.31
gptkbp:foundIn	eukaryotes
gptkbp:function	regulation of cellular energy homeostasis
gptkbp:gene	gptkb:PRKAA1 gptkb:PRKAA2 gptkb:PRKAB1 gptkb:PRKAB2 gptkb:PRKAG1 gptkb:PRKAG2 gptkb:PRKAG3
https://www.w3.org/2000/01/rdf-schema#label	AMPK (AMP-activated protein kinase)
gptkbp:inhibitedBy	gptkb:ATP gptkb:compound_C
gptkbp:involvedIn	gptkb:cancer gptkb:type_2_diabetes obesity response to metabolic stress exercise adaptation
gptkbp:locale	gptkb:nucleus gptkb:cytoplasm
gptkbp:phosphorylates	gptkb:HMG-CoA_reductase gptkb:TSC2 gptkb:acetyl-CoA_carboxylase
gptkbp:regulates	lipid metabolism cell growth glucose uptake protein synthesis autophagy fatty acid oxidation mitochondrial biogenesis mTOR signaling
gptkbp:subunit	beta subunit gamma subunit
gptkbp:UniProtID	gptkb:Q13131
gptkbp:bfsParent	gptkb:AMPK_pathway
gptkbp:bfsLayer	6