AMP-activated protein kinase pathway

GPTKB entity

Predicate	Object
gptkbp:instanceOf	biological pathway
gptkbp:activatedBy	gptkb:metformin gptkb:AMP gptkb:ADP exercise caloric restriction
gptkbp:alsoKnownAs	gptkb:AMPK_pathway
gptkbp:component	cellular stress response metabolic regulation
gptkbp:dysregulationAssociatedWith	gptkb:cancer gptkb:cardiovascular_disease gptkb:type_2_diabetes obesity
gptkbp:foundIn	eukaryotic cells
https://www.w3.org/2000/01/rdf-schema#label	AMP-activated protein kinase pathway
gptkbp:inhibitedBy	gptkb:ATP
gptkbp:involvedIn	gptkb:PRKAA1 gptkb:PRKAA2 gptkb:PRKAB1 gptkb:PRKAB2 gptkb:PRKAG1 gptkb:PRKAG2 gptkb:PRKAG3
gptkbp:involvesProtein	gptkb:TAK1 gptkb:AMP-activated_protein_kinase_(AMPK) gptkb:CaMKKβ gptkb:LKB1
gptkbp:regulates	gptkb:HMG-CoA_reductase gptkb:TSC2 gptkb:ULK1 gptkb:FOXO_transcription_factors gptkb:acetyl-CoA_carboxylase gptkb:PGC-1α apoptosis lipid metabolism cell growth glucose uptake protein synthesis autophagy fatty acid oxidation insulin sensitivity mitochondrial biogenesis cholesterol synthesis glycogen synthesis mTOR signaling GLUT4 translocation cellular energy homeostasis SREBP1
gptkbp:bfsParent	gptkb:AMPK_pathway
gptkbp:bfsLayer	6